2-ethylhexyl_diphenyl_phosphate

2-Ethylhexyl diphenyl phosphate

2-Ethylhexyl diphenyl phosphate

Chemical compound

2-Ethylhexyl diphenyl phosphate (Octicizer) is an organophosphate compound. It acts as both a plasticizer and flame retardant in PVC, its wide liquid range also makes it suitable as a flame retardant in hydraulic fluids. It has low acute toxicity in feeding experiments,[1] but has been implicated as a potential hormone mimetic.[2][3]

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References

  1. [1]
    Treon JF, Dutra FR, Cleveland FP (August 1953). "Toxicity of 2-ethylhexyl diphenyl phosphate. I. Immediate toxicity and effects of long-term feeding experiments". A.M.A. Archives of Industrial Hygiene and Occupational Medicine. 8 (2): 170–84. PMID 13064875.
  2. [2]
    Li J, Zhao L, Letcher RJ, Zhang Y, Jian K, Zhang J, Su G (June 2019). "A review on organophosphate Ester (OPE) flame retardants and plasticizers in foodstuffs: Levels, distribution, human dietary exposure, and future directions". Environment International. 127: 35–51. Bibcode:2019EnInt.127...35L. doi:10.1016/j.envint.2019.03.009. PMID 30901640.
  3. [3]
    Li Y, Kang Q, Chen R, He J, Liu L, Wang L, Hu J (July 2020). "2-Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes)". Environmental Science & Technology. 54 (14): 8919–8925. Bibcode:2020EnST...54.8919L. doi:10.1021/acs.est.0c02775. PMID 32559385. S2CID 219948553.
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