Eugene or Gene Klein may refer to:

• Gene Klein (1921–1990), American entrepreneur and sportsman
• Gene Klein (soccer) (1952–2023), American soccer coach
• Eugene Klein (philatelist) (1878–1944), American stamp collector
• Gene Simmons (born 1949), aka Gene Klein, American rock musician
• Eugene Klein, American cellist with the Delaware Symphony Orchestra

• Jean Klein (disambiguation)
• Gene Clines, American baseball player

This disambiguation page lists articles about people with the same name.
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