The Holtemme is a 47-kilometre (29 mi) long tributary of the river Bode in Saxony-Anhalt, Germany.

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Holtemme
The Steinerne Renne on the upper reaches of the Holtemme
Location
Country	Germany
State	Saxony-Anhalt
Physical characteristics
Source
• location	on the northeastern slopes of the Renneckenberg in the Harz
• elevation	840 m above sea level (HN)
Mouth
• location	near Krottorf into the Bode
• coordinates	51°57′49″N 11°10′59″E
• elevation	97 m above sea level (HN)
Length	47 km (29 mi)
Basin size	271 km2 (105 sq mi)
Basin features
Progression	Bode→ Saale→ Elbe→ North Sea
Landmarks	Large towns: Wernigerode, Halberstadt Small towns: Derenburg

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It rises in the Harz mountains at the eastern foot of the Brocken, descends during its upper course as the Steinerne Renne, a steep stream bed riddled with granite rocks, flows through Hasserode, Wernigerode and past their villages of Minsleben and Silstedt, through Derenburg and Halberstadt and discharges into the Bode.

In Wernigerode, not far from the western gate, the Zillierbach, which is also known as the Flutrenne, merges into the Holtemme.