Isenburg-Birstein was the name of two German historical states centred on Birstein in southeastern Hesse, Germany. The first "Isenburg-Birstein" was a County and was created as a partition of Isenburg-Büdingen-Birstein in 1628. It was merged into Isenburg-Offenbach in 1664. The second "Isenburg-Birstein" was a Principality, created as a partition of Isenburg-Offenbach in 1711. It was renamed the "Principality of Isenburg" in 1806.

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