In Greek mythology, Issa (/ˈiːsɑː/; Ancient Greek: Ἴσσα) or Isse may refer to three people:

• Isse, daughter of Macareus and Canace, children of Aeolus, and a lover of Apollo.^[1] She was usually called Amphissa.^[2]
• Issa, the eponymous nymph of Issa (Lesbos). She became the mother of the prophet Prylis by Hermes.^[3] This son predicted to the Greeks that they would take Troy by means of the Wooden Horse.^[4] She may be the daughter of King Macar and thus, sister of Methymna,^[5] Mytilene, Agamede, Antissa, Arisbe,^[6] Cydrolaus, Neandrus, Leucippus^[7] and Eresus.^[8]
• Achilles, who in some versions of Achilles on Skyros went by the alias Issa when disguised as a girl. In other versions, he was called Pyrrha or Kerkysera.