Fasino was born in 1920 in San Severo, Province of Foggia, Apulia.[2] He was first elected to the Sicilian Regional Assembly in 1951, representing a constituency in Palermo.[1][2] Fasino would win re-election to the Sicilian Regional Assembly for an additional seven terms during his career.[1]
In 1969, Fasino was elected President of Sicily, the head of the regional government.[1] He led five separate Sicilian governments from 1969 until he left the office of the presidency on 22 December 1972.[1]
Two years later, Fasino was elected President of the Sicilian Regional Assembly, succeeding the outgoing speaker, Angelo Bonfiglio, who had been elected to the national Chamber of Deputies.[1][2] Fasino headed the Sicilian Regional Assembly as President from 1974 until 1976.[1]
In 1981, Fasino lost re-election to the Sicilian Regional Assembly.[1][2] However, he returned to the Assembly in 1983 when he was appointed to fill the vacant seat of Mario D'Acquisto, who had been elected to the Chamber of Deputies.[1] Fasino declined to seek re-election to Assembly in 1986, but remained a high-ranking official within the Sicilian regional DC Party.[1] He was also appointed to the Christian Democratic Party (DC) national council.[1]
Fasino later became the President of the Centro di studi filologici e linguistici siciliani (CSFLS) (Center of Philology Studies and Sicilian Language).[1] During the 1990s, Fasino was also appointed to the Sicilian Council of Regional Culture.[1][2]
Mario Fasino died in Palermo, Sicily, on 17 January 2017, at the age of 96.[1][2] His funeral was held at the Santa Maria di Monserrato Church in Palermo.[2]