Markó-Lam_deoxygenation
The Markó–Lam deoxygenation is an organic chemistry reaction where the hydroxy functional group in an organic compound is replaced by a hydrogen atom to give an alkyl group.[1][2] The Markó-Lam reaction is a variant of the Bouveault–Blanc reduction[3] and an alternative to the classical Barton–McCombie deoxygenation. It is named for the Belgian chemists István Markó and Kevin Lam.[4]
The main features of the reaction are:
- short reaction time (5 seconds to 5 minutes).
- the use of a stable toluate derivative.
- the use of SmI2/HMPA system or electrolysis instead of the classical and difficult to remove tributyltin hydride.