P59, P-59 or P.59 may refer to:

• Bell XP-59, a proposed American fighter aircraft
• Bell P-59 Airacomet, an American jet fighter aircraft
• Partenavia P.59 Jolly, a British prototype training aircraft

• HMS Untiring (P59), a submarine of the Royal Navy
• INS Sumitra (P59), a patrol vessel of the Indian Navy
• ORP Sokół (P59), a submarine of the Polish Navy

• p59, an alias of GRASP55, a protein
• Papyrus 59, a biblical manuscript
• P59, a state regional road in Latvia

This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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