TRAF_interacting_protein

TRAF interacting protein

TRAF interacting protein

Protein-coding gene in the species Homo sapiens

TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.[6][7]

Quick Facts TRAIP, Available structures ...
The AlphaFold predicted structure of the TRAIP protein Q9BWF2. The highlighted region has been found to bind to the PCNA PIP box. This image was generated using ChimeraX version 1.7.1.
Detailed view of residue sequence 447-469 of the TRAIP protein in its binding conformation with the PCNA PIP box.[5] This This image was generated using ChimeraX version 1.7.1.

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.[7]

Interactions

TRAF interacting protein has been shown to interact with FLII,[8] TRAF1[6] and TRAF2.[6]

Role in mitotic DNA synthesis

Mitotic DNA synthesis (MiDAS) is thought to be a DNA repair mechanism to salvage DNA that has not finished replication during S phase, which may be due to DNA replication stress (RS).[9] Intrinsic sources of RS include transcription-replication conflicts and “difficult-to-replicate’’ regions.[9] Extrinsic RS includes exposure to genotoxic agents, depletion of dNTPs, and premature S phase activity which can occur in precancerous cells after oncogene activation.[9] Some MiDAS pathways require the TRAIP protein to disassemble the replication complex at the stalled replication fork in cases where RS causes the fork to stall during replication.[9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000183763 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000032586 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, et al. (January 2016). "TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress". The Journal of Cell Biology. 212 (1): 63–75. doi:10.1083/jcb.201506071. PMC 4700480. PMID 26711499.
  6. [6]
    Lee SY, Lee SY, Choi Y (April 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". The Journal of Experimental Medicine. 185 (7): 1275–1285. doi:10.1084/jem.185.7.1275. PMC 2196258. PMID 9104814.
  7. [7]
    "Entrez Gene: TRAIP TRAF interacting protein".
  8. [8]
    Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (August 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research. 26 (15): 3460–3467. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
  9. [9]
    Bhowmick R, Hickson ID, Liu Y (October 2023). "Completing genome replication outside of S phase". Molecular Cell. 83 (20): 3596–3607. doi:10.1016/j.molcel.2023.08.023. PMID 37716351.

Further reading

Stub icon

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article TRAF_interacting_protein, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.