Type_IV_filament

Type IV filament

Type IV filament

Family of cell projections including T2SS and T4P

The type IV filament superfamily (TFF) is a group of fibrous protein structures that includes a set of cell projections with evolutionarily related membrane proteins.[1] The TFF family seems to have originated in the last universal common ancestor, from where it diversified into archaella, type IV pili, type II secretion systems, and the Tad pili.[2]

Complexes in the TFF superfamily are unified by the presence of the eponymous type IV pilin, an AAA+ ATPase, an integral (cytoplasmic) membrane (IM) platform, and (with the exception of MSH) a prepilin peptidase.[2]

References

  1. [1]
    Berry JL, Pelicic V (January 2015). "Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives". FEMS Microbiology Reviews. 39 (1): 134–54. doi:10.1093/femsre/fuu001. PMC 4471445. PMID 25793961.
  2. [2]
    Denise R, Abby SS, Rocha EP (July 2019). Beeby M (ed.). "Diversification of the type IV filament superfamily into machines for adhesion, protein secretion, DNA uptake, and motility". PLOS Biology. 17 (7): e3000390. doi:10.1371/journal.pbio.3000390. PMC 6668835. PMID 31323028.


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Type_IV_filament, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.