Children under age 2 who take antibiotics have a greater risk of developing multiple chronic conditions, according to a new study.

The conditions include childhood-onset asthma, respiratory allergies, eczema , celiac disease, obesity, and attention deficit hyperactivity disorder,  researchers say.

As reported in the journal Mayo Clinic Proceedings , the researchers looked at 14,572 children born in Olmsted County, Minnesota between 2003 and 2011, 70% of whom received at least one antibiotic prescription during their first two years, primarily for respiratory or ear infections.

The findings are consistent with the hypothesis that the composition of the microbiome—the trillions of beneficial microorganisms that live in and on our bodies—plays a critical role in the early development of immunity, metabolism, and behavior.

“The evolution of drug-resistant bacteria exemplifies one unintended consequence of antibiotic overuse ,” says coauthor Martin Blaser, director of the Center for Advanced Biotechnology and Medicine at Rutgers University.

“The increasing prevalence of health conditions that start in childhood has triggered concern about antibiotic exposures during key developmental periods because of their impact on the microbiome.”

While previous studies have looked at the association of antibiotics with single diseases, this is the first to look at the association across many diseases. The researchers found that antibiotics were associated with metabolic diseases (obesity, being overweight), immunological diseases (asthma, food allergies, hay fever), and cognitive conditions or disorders (ADHD, autism).

Effects varied among the different antibiotics. Cephalosporins were associated with the most risk for multiple diseases, and uniquely autism and food allergies.

Researchers also found that risk increased with more courses of antibiotics and when given earlier in life—especially within the first 6 months.

“The findings from Olmsted County provide evidence for broad and delayed effects of early life antibiotic exposures , and should change doctors’ practices in how often they prescribe antibiotics, especially for mild conditions,” Blaser says.

Additional coauthors are from the Mayo Clinic.

Source: Rutgers University

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