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New shingles vaccine may protect lymphoma patients

A new shingles vaccine may work where others have failed for patients with lymphoma, researchers report.

Leslie Orr-Rochester • futurity
Nov. 18, 2020 4 minSource

Vaccines are often ineffective in individuals with lymphoma, but a new shingles vaccine may change that, according to a new study.

Researchers focused on this hard-to-vaccinate group and how best to prevent this particular illness because people with blood cancers are at higher risk of shingles and its complications, which can be fatal in this population.

“This is one of the best vaccine responses anyone has seen in patients with these indolent lymphomas.”

Shingles is a painful reactivation of the chicken pox ( varicella zoster ) virus. It is most common in older adults and can cause debilitating rashes and other health problems.

The shingles vaccine is standard care for everyone over age 50. In people with lymphoma, however, doctors have had two concerns about this vaccine in the past: That a weakened immune system due to B-cell blood cancer does not allow a person to make an effective immune response to the vaccine; and that a common treatment for lymphoma, known as BTK inhibitors, might interrupt or prevent an immune response to the vaccine.

According to the research in Leukemia , 32 lymphoma patients who received a newer version of the shingles vaccine responded favorably. The new vaccine uses an inactivated virus and is safer for people with weakened immune systems.

“This is one of the best vaccine responses anyone has seen in patients with these indolent lymphomas,” says corresponding author, Clive Zent, a hematologist at the Wilmot Cancer Institute at the University of Rochester Medical Center.

The 32 patients with chronic lymphocytic leukemia or lymphoplasmacytic lymphoma were being treated with either ibrutinib or zanabrutinib, drugs within the class of BTK inhibitors. Only 4 of the 32 showed no immune response to the vaccine.

Further studies are needed to confirm the durability of the immune response to the vaccine in patients with lymphoma and poor immune function. Starting in January, Zent says, researchers plan to check the blood of all patients who participated in the study, to investigate the status of their immune responses two years after their last vaccine.

Source: University of Rochester

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