ALS scientific breakthrough: Diabetes drug metformin shows promise in mouse study for a common type of ALS

Amyotrophic lateral sclerosis, Lou Gehrig's disease, is a crippling, progressive neurodegenerative disease for which there is no cure. Now it seems that a diabetes drug may help some cases.

Laura P.W. Ranum, Director, Center for NeuroGenetics and Kitzman Family Professor of Molecular Genetics & Microbiology, University of Florida • conversation
July 20, 2020 ~10 min

Tags:  genetics  brain  neurons  als  mutation  metformin

Drug shows promise for fighting rare ALS

An experimental drug called tofersen that could help treat a rare kind of ALS is headed to a phase 3 trial.

Tamara Bhandari-Washington University • futurity
July 10, 2020 ~7 min

Tags: als drug-development proteins health-and-medicine medications nerves

‘Barcode’ IDs special glial cells in the brain

"...this discovery could be of immense consequence for treating a myriad of brain conditions..."

Brian Clark-Brown • futurity
June 25, 2020 ~5 min

Tags: alzheimers-disease neurons als aging brains muscles health-and-medicine glial-cells neurodegenerative-diseases

Blood plasma analysis could spot signs of ALS

A method of analyzing blood plasma could help diagnose and predict the progression of ALS, researchers report.

Tracey Peake-NC State • futurity
June 3, 2020 ~6 min

Tags: artificial-intelligence als blood plasma featured health-and-medicine neurodegenerative-diseases

Harvard scientists identify gut-brain connection in ALS

The researchers found that in mice with a common ALS genetic mutation, changing the gut microbiome could prevent or improve disease symptoms.

Jessica Lau • harvard
May 13, 2020 ~5 min

Tags: science-technology inflammation als gut-microbiome amyotrophic-lateral-sclerosis gut-brain-axis

Brain cell protection may also regulate your sleep

Understanding more about how a system that protects brain cells affects sleep could reveal a connection between sleep disorders and neurodegenerative diseases.

Lauren Ingeno-Penn • futurity
March 13, 2020 ~5 min

Tags: alzheimers-disease parkinsons-disease als aging sleep brains health-and-medicine neurodegenerative-diseases

Broken ‘rules’ lead to protein clumps in diseases like ALS

New research unveils a way to "read" proteins to see if they'll clump together and contribute to neurodegenerative diseases like ALS.

Brandie Jefferson-WUSTL • futurity
Feb. 26, 2020 ~7 min

Tags: als proteins health-and-medicine neurodegenerative-diseases

Overcharged cell process clears dangerous ALS ‘junk’

Researchers have discovered that a suprising cell process clears out potentially deadly aggregates related to ALS, or amyotrophic lateral sclerosis.

Mikayla Mace-Arizona • futurity
Feb. 13, 2020 ~4 min

Tags: als cells health-and-medicine

FDA-approved drug shows promise against ALS in mice

Accumulating evidence suggests that inflammatory processes may play a role in the initiation and progression of amyotrophic lateral sclerosis (ALS).

Harvard Gazette • harvard
Nov. 27, 2019 ~3 min

Tags:  inflammation  basic-research  health-medicine  als  amyotrophic-lateral-sclerosis  cromolyn-sodium

Turtle spine signals reveal how movement starts

The neurons of itchy turtles show that movement most likely starts in a network of cells, not one "command center."

Anders Buch-Larsen • futurity
Oct. 7, 2019 ~5 min

Tags: spine als movement muscles health-and-medicine nerve-cells spinal-cord-injury

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