Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

Allessandra DiCorato | Broad Institute • mit
Nov. 23, 2023 ~8 min

Thousands of programmable DNA-cutters found in algae, snails, and other organisms

New research finds RNA-guided enzymes called Fanzors are widespread among eukaryotic organisms.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Oct. 13, 2023 ~6 min


A more effective experimental design for engineering a cell into a new state

By focusing on causal relationships in genome regulation, a new AI method could help scientists identify new immunotherapy techniques or regenerative therapies.

Adam Zewe | MIT News • mit
Oct. 2, 2023 ~8 min

Promising assisted reproductive technologies come with ethical, legal and social challenges – a developmental biologist and a bioethicist discuss IVF, abortion and the mice with two dads

Scientists can create viable eggs from two male mice. In the wake of CRISPR controversies and restrictive abortion laws, two experts start a dialogue on ethical research in reproductive biology.

Mary Faith Marshall, Professor of Biomedical Ethics, University of Virginia • conversation
July 13, 2023 ~17 min

Did He Jiankui 'Make People Better'? Documentary spurs a new look at the case of the first gene-edited babies

Scientific and public uproar resulted when the Chinese scientist announced the births of the first human babies with heritable edits to their genes. A new documentary reexamines the saga.

G. Owen Schaefer, Assistant Professor in Biomedical Ethics, National University of Singapore • conversation
Dec. 20, 2022 ~11 min

New CRISPR-based map ties every human gene to its function

Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.

Eva Frederick | Whitehead Institute • mit
June 9, 2022 ~9 min

Convenience-sized RNA editing

MIT neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme.

Sarah CP Williams | McGovern Institute for Brain Research • mit
May 31, 2022 ~6 min

Using plant biology to address climate change

A Climate Grand Challenges flagship project aims to reduce agriculture-driven emissions while making food crop plants heartier and more nutritious.

Merrill Meadow | Whitehead Institute • mit
April 19, 2022 ~9 min


New programmable gene editing proteins found outside of CRISPR systems

Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Sept. 15, 2021 ~6 min

Scientists harness human protein to deliver molecular medicines to cells

Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics.

Broad Institute • mit
Aug. 19, 2021 ~8 min

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