From molecular to whole-brain scale in a simple animal, study reveals serotonin’s effects

With full genetic control and visibility into neural activity and behavior, MIT scientists map out chemical’s role in behavior.

David Orenstein | Picower Institute for Learning and Memory • mit
May 22, 2023 ~7 min

Depression too often gets deemed 'hard to treat' when medication falls short

An overreliance on medication as the first-line treatment for depression can lead some people to be labeled with treatment-resistant depression when there are other viable alternatives for relief.

Jay Kayser, PhD Student in Social Work and Developmental Psychology, University of Michigan • conversation
March 15, 2023 ~12 min


Patients suffering with hard-to-treat depression may get relief from noninvasive magnetic brain stimulation

Patients who undergo transcranial magnetic stimulation say it’s painless, with few to no side effects. The treatment isn’t yet widely accessible, but for those who use it, the effects can be profound.

Patricia Junquera, Associate Professor and Vice Chair of Clinical Services, Florida International University • conversation
Nov. 16, 2022 ~7 min

Uncovering the genetic basis of mental illness requires data and tools that aren't just based on white people – this international team is collecting DNA samples around the globe

Existing genetic data and sequencing tools are overwhelmingly based on people of European ancestry, which excludes much of the rich genetic variation of the world.

Hailiang Huang, Assistant Professor of Medicine, Harvard University • conversation
Sept. 12, 2022 ~9 min

AI maps psychedelic 'trip' experiences to regions of the brain – opening new route to psychiatric treatments

Pinpointing the molecular targets behind the subjective effects of psychedelic drugs could help clinicians and researchers better treat psychiatric conditions.

Sam Friedman, Machine Learning Scientist at the Broad Institute of MIT &, Harvard University • conversation
March 16, 2022 ~6 min

Study shows fragile X treatment can incur resistance, suggests ways around it

While the brain acquires resistance to continuous treatment with mGluR5 inhibitor drugs, lasting effects may still arise if dosing occurs intermittently and during a developmental-critical period.

David Orenstein | Picower Institute for Learning and Memory • mit
Oct. 15, 2021 ~10 min

A new technique for correcting disease-causing mutations

Novel method, developed by McGovern Institute researchers, may lead to safer, more efficient gene therapies.

Jill Crittenden | McGovern Institute for Brain Research • mit
June 9, 2021 ~7 min

Investigating the embattled brain

Combat veteran and PhD candidate Omar Rutledge drives research on post-traumatic stress disorder.

Laura Carter | School of Science • mit
April 28, 2021 ~7 min


Hoarding, stockpiling, panic buying: What's normal behavior in an abnormal time?

The pandemic has put a spotlight on a once little-discussed disorder – hoarding. But hoarding disorder is not what you might think.

Carol Mathews, Professor of Psychiatry, University of Florida • conversation
Nov. 17, 2020 ~8 min

A new paper examines how neuron-like implants could treat brain disorders

A new paper explores why neuron-like implants could offer a better way to treat brain disorders, control prosthetics, or even enhance cognitive abilities.

Caitlin McDermott-Murphy • harvard
Sept. 20, 2019 ~6 min

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