Sepsis is one of the most expensive medical conditions in the world – new research clarifies how it can lead to cell death

An overactive immune response to infection can be deadly. Studying how one key player called tumor necrosis factor, or TNF, induces lethal immune responses could provide new treatment targets.

Hayley Muendlein, Research Assistant Professor of Immunology, Tufts University • conversation
Dec. 23, 2022 ~7 min

Nasal vaccines promise to stop the COVID-19 virus before it gets to the lungs – an immunologist explains how they work

An effective nasal vaccine could stop the virus that causes COVID-19 right at its point of entry. But devising one that works has been a challenge for researchers.

Michael W. Russell, Professor Emeritus of Microbiology and Immunology, University at Buffalo • conversation
Dec. 14, 2022 ~9 min


What is inflammation? Two immunologists explain how the body responds to everything from stings to vaccination and why it sometimes goes wrong

Inflammation is a complicated and important part of how the immune system responds to threats to the body. But when the inflammatory response goes awry, it can lead to serious problems.

Mitzi Nagarkatti, Professor of Pathology, Microbiology and Immunology, University of South Carolina • conversation
Nov. 7, 2022 ~6 min

Viruses may be 'watching' you – some microbes lie in wait until their hosts unknowingly give them the signal to start multiplying and kill them

Phages, or viruses that infect bacteria, can lie dormant within chromosomes until they’re triggered to replicate and burst out of their hosts.

Ivan Erill, Associate Professor of Biological Sciences, University of Maryland, Baltimore County • conversation
Sept. 15, 2022 ~8 min

Monkeypox vaccines: A virologist answers 6 questions about how they work, who can get them and how well they prevent infection

There are two approved monkeypox vaccines in the US. Both use a related poxvirus called vaccinia to produce an immune response that protects against smallpox and monkeypox.

Maureen Ferran, Associate Professor of Biology, Rochester Institute of Technology • conversation
Aug. 4, 2022 ~8 min

Long COVID-19 and other chronic respiratory conditions after viral infections may stem from an overactive immune response in the lungs

While a strong immune response is essential to fight against viral infection, an immune system that continues to stay active long after the virus has been cleared can lead to lung damage.

Harish Narasimhan, PhD Candidate in Immunology, University of Virginia • conversation
Aug. 4, 2022 ~7 min

Sepsis still kills 1 in 5 people worldwide – two ICU physicians offer a new approach to stopping it

Sepsis onset can be difficult to recognize, in part because its symptoms can mimic those of many other conditions. A treatment delay of even a few hours can make the difference between life and death.

Kristina E. Rudd, Assistant Professor of Critical Care Medicine, University of Pittsburgh Health Sciences • conversation
June 10, 2022 ~10 min

COVID-19 official counts can miss mild cases – here's how serosurveys that analyze blood for signs of past infection can help

Your blood can hold a record of past illnesses. That information can reveal how many people have had a certain infection – like 58% of Americans having had COVID-19 by the end of February 2022.

Isobel Routledge, Postdoctoral Scholar in Medicine, University of California, San Francisco • conversation
May 6, 2022 ~9 min


What's the difference between a PCR and antigen COVID-19 test? A molecular biologist explains

The two types of COVID-19 tests – antigen and PCR – work in very different ways, which is why one is fast but less accurate and the other is slow and precise.

Nathaniel Hafer, Assistant Professor, Program in Molecular Medicine, UMass Chan Medical School • conversation
Nov. 8, 2021 ~8 min

Pregnant or worried about infertility? Get vaccinated against COVID-19

A COVID-19 vaccine does not cause infertility – but it can protect you from the dangerous complications of contracting the virus.

Matthew Woodruff, Instructor of Human Immunology, Emory University • conversation
Aug. 25, 2021 ~9 min

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