Which drugs and therapies are proven to work, and which ones don't, for COVID-19?

During the last six months, news reports have mentioned dozens of drugs that may be effective against the new coronavirus. Here we lay out the evidence and reveal which ones are proven to work. Or not.

William Petri, Professor of Medicine, University of Virginia • conversation
July 1, 2020 ~7 min

Tags: covid-19 coronavirus pandemic sars-cov-2 remdesivir severe-acute-respiratory-syndrome-sars mers-cov hydroxychloroquine chloroquine ace2 treatments cytokine-storm steroids ace-inhibitors

Coronavirus may wane this summer, but don't count on any seasonal variation to end the pandemic

Winter is flu season – could it be coronavirus season as well? The research is mixed, but other factors besides temperature and humidity have more to do with the spread of SARS-CoV-2.

Ellen Wright Clayton, Professor of Pediatrics and Law and Health Policy, Vanderbilt University • conversation
April 15, 2020 ~5 min

Tags: infectious-diseases covid-19 sars-cov-2 heat severe-acute-respiratory-syndrome-sars viruses mers-cov temperature humidity infectious-disease-research us-national-academy-of-sciences national-academies seasonal-flu flu-season

Study shows pangolins may have passed new coronavirus from bats to humans

When a new virus emerges and triggers a pandemic, it is important to trace its origins. Knowing more about how the virus jumped species in the first place can help curb future zoonotic diseases.

Wei Zheng, Postdoctoral Fellow of Computational Medicine and Bioinformatics, University of Michigan • conversation
April 10, 2020 ~7 min

Tags: covid-19 pandemic sars-cov-2 severe-acute-respiratory-syndrome-sars sars-cov mers-cov zoonotic-viruses bat pangolin

What the coronavirus does to your body that makes it so deadly

The new coronavirus, SARS-CoV-2, spreads faster than the H1N1 influenza virus and is much deadlier. SARS-CoV-2 is particularly skilled at keeping cells from calling out for help.

Benjamin Neuman, Professor of Biology, Texas A&M University-Texarkana • conversation
April 2, 2020 ~8 min

Tags:  influenza  infectious-diseases  epidemiology  covid-19  coronavirus  immune-system  pandemic  blood-pressure  vaccines  sars-cov-2  viruses  new-coronavirus  mers-cov  virology

Could chloroquine treat coronavirus? 5 questions answered about a promising, problematic and unproven use for an antimalarial drug

A medicinal chemist addresses questions about chloroquine and hydroxychloroquine: what it is, whether it is effective against COVID-19 and whether it can treat and/or prevent this disease.

Katherine Seley-Radtke, Professor of Chemistry and Biochemistry and President-Elect of the International Society for Antiviral Research, University of Maryland, Baltimore County • conversation
March 25, 2020 ~6 min

Tags:  covid-19  antiviral-drugs  viruses  sars-cov  mers-cov  antimalarial

Why don't viruses make their original hosts sick? 5 questions answered

Many of these new diseases cross over, jumping from wild animals to people.

Marcos E. García-Ojeda, Professor of Molecular and Cell Biology, University of California, Merced • conversation
March 13, 2020 ~7 min

Tags:  covid-19  severe-acute-respiratory-syndrome-sars  coronavirus-2020  mers-cov

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