Nitazenes found in 5 overdose deaths in Philly – here’s what they are and why they’re so deadly

Initially developed in the 1950s, nitazenes are a type of synthetic opioid that has reappeared in Philadelphia’s street drug supply.

Christopher P. Holstege, Professor of Emergency Medicine and Pediatrics, University of Virginia • conversation
April 12, 2024 ~6 min

Nearly 2 million Americans are using kratom yearly, but it is banned in multiple states: A pharmacologist explains the controversy

Long-term use of kratom may actually reduce pain tolerance and cause physical dependence and withdrawal symptoms.

C. Michael White, Distinguished Professor of Pharmacy Practice, University of Connecticut • conversation
Feb. 20, 2024 ~8 min


Nitazenes are a powerful class of street drugs emerging across the US

An overdose death in Boulder County, Colorado, was linked to a powerful new formulation of a designer drug never approved for use in humans.

Christopher P. Holstege, Professor of Emergency Medicine and Pediatrics, University of Virginia • conversation
Feb. 15, 2024 ~6 min

Untrained bystanders can administer drone-delivered naloxone, potentially saving lives of opioid overdose victims

The study discovered that nonmedical personnel can provide the naloxone to an overdose victim in about one minute.

Nicole Adams, Clinical Associate Professor of Nursing, Purdue University • conversation
Jan. 22, 2024 ~5 min

Dozens of US adolescents are dying from drug overdoses every month − an expert on substance use unpacks the grim numbers with 3 charts

Among adolescents, boys are more likely to die of an overdose than girls, and using combinations of drugs substantially raises the risk of an overdose.

Ty Schepis, Professor of Psychology, Texas State University • conversation
Nov. 27, 2023 ~7 min

Philadelphia bans supervised injection sites – evidence suggests keeping drug users on the street could do more harm than good

A group of academics look at the global evidence to examine the potential impact of safe injection sites in Philadelphia and the US.

Tony Joakim Ananiassen Sandset, Researcher Fellow at the Centre for Sustainable Healthcare Education, University of Oslo • conversation
Oct. 12, 2023 ~10 min

Philadelphia bans safe injection sites – evidence suggests keeping drug users on the street could do more harm than good

A group of academics look at the global evidence to examine the potential impact of safe injection sites in Philadelphia and the US.

Tony Joakim Ananiassen Sandset, Researcher Fellow at the Centre for Sustainable Healthcare Education, University of Oslo • conversation
Oct. 12, 2023 ~10 min

Myths about will power and moral weakness keep people with opioid use disorder from receiving effective medications like methadone, buprenorphine and naltrexone

Prescription medications can help people with opioid use disorder avoid the risks of relapse and overdose. But stigma based on misperceptions about addiction limits their use.

Melissa Cyders, Professor of Psychology, Indiana University • conversation
July 13, 2023 ~6 min


Your body naturally produces opioids without causing addiction or overdose – studying how this process works could help reduce the side effects of opioid drugs

Unlike opioid drugs like morphine and fentanyl that travel throughout the body, the opioids your body produces are released in small quantities to specific locations.

John Michael Streicher, Associate Professor of Pharmacology, University of Arizona • conversation
May 30, 2023 ~7 min

What is xylazine? A medical toxicologist explains how it increases overdose risk, and why Narcan can still save a life

Xylazine, or tranq, is increasingly being mixed with drugs like fentanyl or heroin and can be difficult to detect. Most people who use drugs are unable to tell if they have been exposed to it.

Kavita Babu, Professor of Emergency Medicine, UMass Chan Medical School • conversation
March 28, 2023 ~4 min

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