Hallmarks of dementia found well before diagnosis
A new study shows the impact of early amyloid-β and tau protein accumulation on disrupting brain connections important for memory. These disrupted connections were present even before signs of cognitive impairment were observed.
May 2, 2022 • ~5 min
New tool developed to study ‘undruggable’ proteins
Researchers at Harvard have designed new, highly selective tools that can add or remove sugars from a protein with no off-target effects, to examine exactly what the sugars are doing and engineer them into new treatments for “undruggable” proteins.
April 16, 2021 • ~7 min
Tracking protein buildup before Alzheimer’s takes hold
A team led by investigators has now developed an automated method that can identify and track the development of two key abnormal protein deposits that accumulate in the brain during the development of Alzheimer’s disease.
Feb. 2, 2021 • ~4 min
After his wife was diagnosed with Alzheimer’s, Arthur Kleinman shares what he learned
Harvard Professor Arthur Kleinman’s wife, Joan, began to struggle with a rare form of early Alzheimer’s disease at 59. Eight years after losing her, he chronicles their journey in “The Soul of Care: The Moral Education of a Husband and a Doctor.”
Oct. 31, 2019 • ~10 min
Harvard unveils new technique 60 times faster than traditional fMRI
Researchers from Brigham and Women’s Hospital, King’s College London, and other institutions have developed a technique for measuring brain activity that’s 60 times faster than traditional fMRI.
April 17, 2019 • ~8 min
Exercise, fasting shown to help cells shed defective proteins
A new study from the Blavatnik Institute finds that intense exercise and fasting activate hormones that boost cells’ capacity to dispose of defective proteins, which clog up the cell, interfere with its functions, and, over time, precipitate diseases including neurodegenerative conditions such as ALS and Alzheimer’s.
Feb. 21, 2019 • ~9 min
/
1