Removing the constraining requirements at gene editing site

Investigators at Massachusetts General Hospital have modified the gene editing system, making it possible to potentially target any location across the entire human genome.

Harvard Gazette
March 26, 2020 | harvard

~3 mins   

Tags: science-technology basic-research benjamin-p-kleinstiver blindness cancer cas9 center-for-genomic-medicine crispr gene-editing mgh

Special ice solution injected under skin is shown to reduce fat

The lab that invented cryolipolisis or “Coolsculpting,” a popular nonsurgical method for reducing fat under the skin, is developing a promising new form of the technology that can selectively reduce fat almost anywhere in the body using an injectable ice solution or “slurry.”

Harvard Gazette
Jan. 15, 2020 | harvard

~5 mins   

Tags: health-medicine basic-research coolsculpting cryolipolisis fat-cells fat-deposits lilit-garibyan mgh wellman-center-for-photomedicine

Trial shows antihypertension drug may improve pancreatic cancer outcomes

Adding the blood-pressure drug losartan to the intensive chemo and radiation protocol for treating locally advanced pancreatic cancer allowed complete removal of the tumor in 61 percent of trial participants and significantly improved survival rates.

Sue McGreevey
May 30, 2019 | harvard

~5 mins   

Tags: health-medicine blood-pressure carlos-fernandez-del-castillo janet-murphy jennifer-wo losartan massachusetts-general-hospital mgh pancreatic-cancer rakesh-k-jain theodore-hang

Mass. General researchers develop 3-D ‘mini-gut’ model to study response to gluten

Researchers at Massachusetts General Hospital have created miniature, simplified versions of the intestine in vitro to explore how the gut lining and microbiome respond to gluten in both healthy and celiac patients.

Susie Flaherty
May 9, 2019 | harvard

~4 mins   

Tags: health-medicine alessio-fasano anna-sapone anthony-anselmo celiac-disease gloria-serena gluten laura-ingano mass-general massachusetts-general-hospital mgh mibrc mucosal-immunology-and-biology-research-center murat-cetinbas organoids rachel-freire ruslan-sadreyev stefania-senger

Harvard undergrad’s AI model helps to predict TB resistance

A Harvard undergrad, working with Harvard Medical School scientists, has designed an artificial intelligence model that predicts tuberculosis resistance to 10 most commonly used drugs. The new model outperforms previous machine-learning tools, and incorporating it into clinical tests could dramatically enhance early detection and prompt treatment of drug-resistant TB.

Ekaterina Pesheva
May 2, 2019 | harvard

~11 mins   

Tags: science-technology akshith-doddi analysis-group andy-beam bill-and-melinda-gates-foundation blavatnik-institute critical-path-institute drug-resistance ebiomedicine gentb harvard-medical-school harvard-th-chan-school-of-public-health hms isaac-kohane jimmy-royer luca-freschi marco-schito masha-farhat massachusetts-general-hospital matthew-ezewudo mdr-tb mgh michael-chen tb tuberculosis university-of-virginia-school-of-medicine xdr-tb

Harvard undergrad’s AI model predicts TB resistance

A Harvard undergrad, working with Harvard Medical School scientists, has designed an artificial intelligence model that predicts tuberculosis resistance to 10 most commonly used drugs. The new model outperforms previous machine-learning tools, and incorporating it into clinical tests could dramatically enhance early detection and prompt treatment of drug-resistant TB.

Ekaterina Pesheva
May 2, 2019 | harvard

~11 mins   

Tags: science-technology akshith-doddi analysis-group andy-beam bill-and-melinda-gates-foundation blavatnik-institute critical-path-institute drug-resistance ebiomedicine gentb harvard-medical-school harvard-th-chan-school-of-public-health hms isaac-kohane jimmy-royer luca-freschi marco-schito masha-farhat massachusetts-general-hospital matthew-ezewudo mdr-tb mgh michael-chen tb tuberculosis university-of-virginia-school-of-medicine xdr-tb

76 more gene regions found associated with sleep duration

Scientists from Massachusetts General Hospital and the University of Exeter Medical School have identified another 76 gene regions associated with sleep duration. Their findings may underpin future investigations into disordered sleep and understanding individual set points for how much is enough.

Sue McGreevey
March 8, 2019 | harvard

~6 mins   

Tags: health-medicine early-riser genome-wide-association-study hassan-saeed-dashti massachusetts-general-hospital mgh nature-communications night-owl richa-saxena samuel-jones uk-biobank university-of-exeter-medical-school

Interaction between immune factors triggers cancer-promoting chronic inflammation

Harvard researchers found that interaction between immune factors triggers cancer-promoting chronic inflammation, setting the stage for the development of skin cancer associated with chronic dermatitis and colorectal cancer in patients with colitis.

Sue McGreevey
Feb. 11, 2019 | harvard

~4 mins   

Tags: health-medicine cancer cancer-promoting-inflammation colon-cancer cutaneous-biology-research-center immune-factor-il-33 inflammation massachusetts-general-hospital mgh mgh-center-for-cancer-immunology pnas shawn-demehri skin-cancer t-cells

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