Taking a moonshot at a rare childhood cancer

Team of researchers including MIT Professor Angela Koehler obtains $5.8 million grant to study fusion-positive alveolar rhabdomyosarcoma.

Bendta Schroeder | Koch Institute | Nov. 20, 2019 | mit
~6 mins   

Tags: koch-institute broad-institute biological-engineering school-of-engineering cancer medicine grants research national-institutes-of-health-nih funding biology

Biological engineer Paul Blainey creates new tools to advance biomedical research

His technology platforms have benefited genomics, diagnostics, and drug screening.

Anne Trafton | MIT News Office | Oct. 19, 2019 | mit
~8 mins   

Tags: research biological-engineering faculty broad-institute school-of-engineering profile imaging microfluidics genetics drug-development

Technique can image individual proteins within synapses

Rapid imaging method could help reveal how conditions such as autism affect brain cells.

Anne Trafton | MIT News Office | Sept. 26, 2019 | mit
~7 mins   

Tags: research biological-engineering broad-institute school-of-engineering neuroscience dna synapses imaging national-institutes-of-health-nih national-science-foundation-nsf

A comprehensive catalogue of human digestive tract bacteria

Researchers identify nearly 8,000 strains of bacteria, while also clarifying their genetic and metabolic context.

Anne Trafton | MIT News Office | Sept. 2, 2019 | mit
~7 mins   

Tags: research biological-engineering civil-and-environmental-engineering microbes basteria health genetics broad-institute school-of-engineering

Neuroscientists identify brain region linked to altered social interactions in autism model

In a mouse model, restoring activity of a specific forebrain region reverses social traits associated with autism.

Sabbi Lall | McGovern Institute for Brain Research | July 26, 2019 | mit
~4 mins   

Tags: mcgovern-institute broad-institute brain-and-cognitive-sciences school-of-science autism genetics research neuroscience

New CRISPR platform expands RNA editing capabilities

The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.

Sabbi Lall | McGovern Institute for Brain Research | July 11, 2019 | mit
~6 mins   

Tags: mcgovern-institute broad-institute brain-and-cognitive-sciences biological-engineering school-of-science crispr school-of-engineering rna dna genetics research

A chemical approach to imaging cells from the inside

Researchers develop a new microscopy system for creating maps of cells, using chemical reactions to encode spatial information.

Karen Zusi | Broad Institute | June 20, 2019 | mit
~4 mins   

Tags: research rna dna broad-institute biological-engineering brain-and-cognitive-sciences mcgovern-institute school-of-science school-of-engineering imaging microscopy

Using gene editing, neuroscientists develop a new model for autism

By introducing a gene variant associated with autism into monkeys, researchers hope to study treatment options for severe neurodevelopmental disorders.

Anne Trafton | MIT News Office | June 12, 2019 | mit
~9 mins   

Tags: research autism crispr genome-editing brain-and-cognitive-sciences neuroscience mcgovern-institute broad-institute school-of-science school-of-engineering china

New gene-editing system precisely inserts large DNA sequences into cellular DNA

Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.

Karen Zusi | Broad Institute | June 12, 2019 | mit
~7 mins   

Tags: research crispr genome-editing rna dna genetics broad-institute mcgovern-institute biological-engineering brain-and-cognitive-sciences school-of-science school-of-engineering

Keeping genetic engineering localized

Researchers are developing a so-called "daisy-chain" gene-drive system that provides controls for genetic engineering of certain populations.

Helen Knight | MIT Media Lab | April 2, 2019 | mit
~7 mins   

Tags: research genetics evolution disease genetic-engineering ethics media-lab school-of-architecture-and-planning broad-institute crispr

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