Nature-inspired CRISPR enzymes for expansive genome editing

Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.

Media Lab • mit
May 19, 2020 ~6 min

Tags: media-lab center-for-bits-and-atoms crispr genome-editing computational-biology dna rna covid-19 research school-of-architecture-and-planning alumniae

SHERLOCK-based one-step test provides rapid and sensitive Covid-19 detection

New CRISPR-based research tool delivers results in an hour; researchers share protocol and kits to advance research and move toward clinical validation.

Sabbi Lall | McGovern Institute for Brain Research • mit
May 5, 2020 ~8 min

Tags: research covid-19 medicine pandemic health-science-and-technology brain-and-cognitive-sciences school-of-science broad-institute crispr viruses dna public-health

Newly discovered enzyme “square dance” helps generate DNA building blocks

MIT biochemists can trap and visualize an enzyme as it becomes active — an important development that may aid in future drug development.

Raleigh McElvery | Department of Biology • mit
March 30, 2020 ~5 min

Tags: biology school-of-science chemistry disease dna energy health research biochemistry

Historic migration patterns are written in Americans' DNA

Genetic, geographic, and demographic data from more than 30,000 Americans reveal more genetic diversity within ancestry groups than previously thought.

Tom Ulrich | Broad Institute • mit
March 5, 2020 ~4 min

Tags: research broad-institute genetics school-of-engineering school-of-architecture-and-planning urban-studies-and-planning electrical-engineering-computer-science-eecs dna

Screen could offer better safety tests for new chemicals

Using specialized liver cells, a new test can quickly detect potentially cancer-causing DNA damage.

Anne Trafton | MIT News Office • mit
Dec. 17, 2019 ~7 min

Tags: research cancer biological-engineering school-of-engineering national-institutes-of-health-nih drug-development dna health-sciences-and-technology environment

A new way to regulate gene expression

Biologists uncover an evolutionary trick to control gene expression that reverses the flow of genetic information from RNA splicing back to transcription.

Raleigh McElvery | Department of Biology • mit
Dec. 9, 2019 ~6 min

Tags: biology school-of-science data disease dna evolution genetics health research national-institutes-of-health-nih

How biomarkers can record and reconstruct climate trends

Scientists reveal the genes and proteins controlling the chemical structure of a paleoclimate biomarker.

Fatima Husain | EAPS • mit
Dec. 4, 2019 ~5 min

Tags: eaps school-of-science research climate ocean-science dna biology geology climate-change microbes evolution genetics bacteria earth-and-atmospheric-sciences national-science-foundation-nsf department-of-energy-doe

Technique can image individual proteins within synapses

Rapid imaging method could help reveal how conditions such as autism affect brain cells.

Anne Trafton | MIT News Office • mit
Sept. 26, 2019 ~7 min

Tags: research biological-engineering broad-institute school-of-engineering neuroscience dna synapses imaging national-institutes-of-health-nih national-science-foundation-nsf

Using CRISPR to program gels with new functions

Smart materials change properties in response to specific DNA sequences; could be used in a variety of devices.

Anne Trafton | MIT News Office • mit
Aug. 22, 2019 ~6 min

Tags: research dna crispr genetics diagnostic-devices drug-delivery biological-engineering institute-for-medical-engineering-and-science-imes school-of-engineering


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