Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

Allessandra DiCorato | Broad Institute • mit
Nov. 23, 2023 ~8 min

Smart pill can track key biological markers in real-time

Coupling engineered bacteria with low-power electronics could be highly effective in diagnosis, treatment of bowel diseases.

Elizabeth A. Thomson | Materials Research Laboratory • mit
Sept. 8, 2023 ~8 min


Researchers uncover a new CRISPR-like system in animals that can edit the human genome

The first RNA-guided DNA-cutting enzyme found in eukaryotes, Fanzor could one day be harnessed to edit DNA more precisely than CRISPR/Cas systems.

Leah Eisenstadt | McGovern Institute for Brain Research | Broad Institute • mit
June 28, 2023 ~7 min

Inaugural J-WAFS Grand Challenge aims to develop enhanced crop variants and move them from lab to land

Matt Shoulders will lead an interdisciplinary team to improve RuBisCO — the photosynthesis enzyme thought to be the holy grail for improving agricultural yield.

Carolyn Blais | Abdul Latif Jameel Water and Food Systems Lab • mit
May 10, 2023 ~14 min

New CRISPR-based map ties every human gene to its function

Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.

Eva Frederick | Whitehead Institute • mit
June 9, 2022 ~9 min

Convenience-sized RNA editing

MIT neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme.

Sarah CP Williams | McGovern Institute for Brain Research • mit
May 31, 2022 ~6 min

New programmable gene editing proteins found outside of CRISPR systems

Researchers find RNA-guided enzymes are more diverse and widespread than previously believed.

Jennifer Michalowski | McGovern Institute for Brain Research • mit
Sept. 15, 2021 ~6 min

A new technique for correcting disease-causing mutations

Novel method, developed by McGovern Institute researchers, may lead to safer, more efficient gene therapies.

Jill Crittenden | McGovern Institute for Brain Research • mit
June 9, 2021 ~7 min


An on-off switch for gene editing

New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged.

Eva Frederick | Whitehead Institute • mit
April 14, 2021 ~9 min

Making real a biotechnology dream: nitrogen-fixing cereal crops

Voigt Lab's work could eventually replace cereal crops’ need for nitrogen from chemical fertilizers.

Lisa Miller | Abdul Latif Jameel Water and Food Systems Lab • mit
Jan. 10, 2020 ~9 min

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