Bringing RNA into genomics

ENCODE consortium identifies RNA sequences that are involved in regulating gene expression.

Anne Trafton | MIT News Office • mit
July 29, 2020 ~7 min

Tags: genetics biology rna research school-of-science

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
July 21, 2020 ~7 min

Tags: neuroscience rna immunology broad-institute research cells school-of-science brain-and-cognitive-sciences computer-science-and-artificial-intelligence-laboratory-csail picower-institute huntingtons

Nature-inspired CRISPR enzymes for expansive genome editing

Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.

Media Lab • mit
May 19, 2020 ~6 min

Tags: dna crispr covid-19 rna research computational-biology media-lab school-of-architecture-and-planning alumniae genome-editing center-for-bits-and-atoms

SMART researchers receive grant to develop rapid tests for Covid-19

Using engineered binder proteins to detect viral proteins or antibodies rather than RNA, new tests may overcome current challenges in testing for SARS-CoV-2 virus.

Singapore-MIT Alliance for Research and Technology • mit
May 19, 2020 ~9 min

Tags: health public-health covid-19 pandemic rna disease research proteins school-of-engineering grants singapore-mit-alliance-for-research-and-technology-smart

HIV genome bends over backwards to help virus take over cells

Differently shaped RNA molecules allow HIV to express different genes from the same RNA sequence.

Eva Frederick | Whitehead Institute • mit
May 11, 2020 ~9 min

Tags: medicine genetics hivaids biology rna disease viruses research computer-science-and-technology algorithms whitehead-institute


Delivery system can make RNA vaccines more powerful

Vaccines packaged in novel nanoparticles could offer a new way to fight cancer and infectious diseases.

Anne Trafton | MIT News Office • mit
Sept. 30, 2019 ~5 min

Tags: cancer ebola rna vaccines disease research school-of-engineering koch-institute chemical-engineering institute-of-medical-engineering-and-science-imes

An emerging view of RNA transcription and splicing

Whitehead Institute scientists find chemical modification contributes to trafficking between non-membrane-bound compartments that control gene expression.

Nicole Davis | Whitehead Institute • mit
Aug. 9, 2019 ~6 min

Tags: dna genetics biology rna research school-of-science whitehead-institute

New CRISPR platform expands RNA editing capabilities

The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.

Sabbi Lall | McGovern Institute for Brain Research • mit
July 11, 2019 ~6 min

Tags: dna genetics crispr rna broad-institute research school-of-engineering school-of-science brain-and-cognitive-sciences biological-engineering mcgovern-institute

A chemical approach to imaging cells from the inside

Researchers develop a new microscopy system for creating maps of cells, using chemical reactions to encode spatial information.

Karen Zusi | Broad Institute • mit
June 20, 2019 ~4 min

Tags: dna imaging microscopy rna broad-institute research school-of-engineering school-of-science brain-and-cognitive-sciences biological-engineering mcgovern-institute

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