RNA molecules are masters of their own destiny

Research suggests the products of transcription — RNA molecules — regulate their own production through a feedback loop.

Eva Frederick | Whitehead Institute • mit
Jan. 5, 2021 ~8 min

physics chemistry genetics biology rna research drug-development school-of-engineering school-of-science whitehead-institute chemical-engineering

3 Questions: Phillip Sharp on the discoveries that enabled RNA vaccines for Covid-19

Curiosity-driven basic science in the 1970s laid the groundwork for today’s leading vaccines against the novel coronavirus.

School of Science • mit
Dec. 11, 2020 ~9 min

genetics covid-19 biology pandemic rna vaccines history-of-science research school-of-science faculty 3-questions koch-institute

Regulating the regulators

Tiny microRNAs help destroy unwanted messenger RNAs in cells. New research finds how the body keeps them in check.

Eva Frederick | Whitehead Institute • mit
Nov. 24, 2020 ~6 min

genetics crispr biology rna research whitehead-institute

Silencing gene expression to cure complex diseases

Immuneering uses bioinformatics to develop new medicines while also helping large pharmaceutical companies improve their treatments.

Zach Winn | MIT News Office • mit
Oct. 26, 2020 ~9 min

health medicine genetics cancer startups biology rna alzheimers data disease research drug-development school-of-engineering innovation-and-entrepreneurship-ie alumniae biological-engineering

Nanoparticles can turn off genes in bone marrow cells

Using these new particles, researchers could develop treatments for heart disease and other conditions.

Anne Trafton | MIT News Office • mit
Oct. 5, 2020 ~8 min

genetics rna research school-of-engineering nanoscience-and-nanotechnology koch-institute institute-for-medical-engineering-and-science-imes chemical-engeering

Scientists discover new rules about “runaway” transcription

Findings related to bacterial gene expression overturn fundamental assumptions about basic biological pathways.

Raleigh McElvery | Department of Biology • mit
Sept. 2, 2020 ~7 min

dna physics genetics bacteria biology rna research school-of-science

Bringing RNA into genomics

ENCODE consortium identifies RNA sequences that are involved in regulating gene expression.

Anne Trafton | MIT News Office • mit
July 29, 2020 ~7 min

genetics biology rna research school-of-science

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
July 21, 2020 ~7 min

neuroscience rna immunology broad-institute research cells school-of-science brain-and-cognitive-sciences computer-science-and-artificial-intelligence-laboratory-csail picower-institute huntingtons

Nature-inspired CRISPR enzymes for expansive genome editing

Applied computational biology discoveries vastly expand the range of CRISPR’s access to DNA sequences.

Media Lab • mit
May 19, 2020 ~6 min

dna crispr covid-19 rna research computational-biology media-lab school-of-architecture-and-planning alumniae genome-editing center-for-bits-and-atoms

SMART researchers receive grant to develop rapid tests for Covid-19

Using engineered binder proteins to detect viral proteins or antibodies rather than RNA, new tests may overcome current challenges in testing for SARS-CoV-2 virus.

Singapore-MIT Alliance for Research and Technology • mit
May 19, 2020 ~9 min

health public-health covid-19 pandemic rna disease research proteins school-of-engineering grants singapore-mit-alliance-for-research-and-technology-smart

/

5