HIV genome bends over backwards to help virus take over cells

Differently shaped RNA molecules allow HIV to express different genes from the same RNA sequence.

Eva Frederick | Whitehead Institute • mit
May 11, 2020 ~9 min

Tags: whitehead-institute biology viruses rna hivaids genetics algorithms medicine research disease computer-science-and-technology

Putting a finger on the switch of chronic parasite infection

Researchers find master regulator needed for Toxoplasma gondii parasite to chronically infect host; promising step toward infection treatment, prevention.

Greta Friar | Whitehead Institute • mit
Jan. 21, 2020 ~6 min

Tags: whitehead-institute biology chemistry disease genetics crispr medicine research parasites school-of-science

Whitehead Institute team resolves structure of master growth regulator

New research reveals how mTORC1 docks at lysosomal surface.

Nicole Davis | Whitehead Institute • mit
Oct. 18, 2019 ~6 min

Tags: whitehead-institute biology school-of-science national-institutes-of-health-nih research drug-discovery

Ruth Lehmann elected as director of Whitehead Institute

Lehmann, a world-renowned developmental and cell biology researcher, is the institute’s fifth director.

Lisa Girard | Whitehead Institute • mit
Sept. 19, 2019 ~9 min

Tags: whitehead-institute school-of-science biology research administration cells


An emerging view of RNA transcription and splicing

Whitehead Institute scientists find chemical modification contributes to trafficking between non-membrane-bound compartments that control gene expression.

Nicole Davis | Whitehead Institute • mit
Aug. 9, 2019 ~6 min

Tags: whitehead-institute biology school-of-science genetics research rna dna


Speeding up drug discovery for brain diseases

Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder.

Nicole Davis • mit
July 31, 2019 ~6 min

Tags: whitehead-institute picower-institute school-of-science behavior biology brain-and-cognitive-sciences crispr development disease genetics mental-health national-institutes-of-health-nih pharmaceuticals research proteins drug-development

Uncovering the riches of traditional global medicine

Researchers solve how the kava plant produces its pain-relieving and anti-anxiety molecules, demonstrate an extensible method to scale and optimize production.

Greta Friar | Whitehead Institute • mit
July 23, 2019 ~7 min

Tags: whitehead-institute biology school-of-science evolution genetics mental-health national-science-foundation-nsf research health plants

Genetic study takes research on sex differences to new heights

Differences in male and female gene expression, including those contributing to height differences, found throughout the body in humans and other mammals.

Greta Friar | Whitehead Institute • mit
July 18, 2019 ~8 min

Tags: whitehead-institute school-of-science biology evolution genetics national-institutes-of-health-nih research animals

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