New 3D mini brain models accelerate neuroscience research

Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.

Harvard Gazette | June 5, 2019 | harvard
~8 mins   

Tags: science-technology aviv-regev basic-research brain broad-insitute crispr doug-melton neuroscience organoids paola-arlotta reproducibility silvia-velasco single-cell-sequencing steven-hyman yoshiki-sasai

Broad Institute researchers develop 3D mini brain models

Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain “organoids” — miniature 3D organ models — so they consistently follow growth patterns observed in the developing human brain.

Harvard Gazette | June 5, 2019 | harvard
~8 mins   

Tags: science-technology aviv-regev basic-research brain crispr doug-melton neuroscience organic paola-arlotta reproducibility silvia-velasco single-cell-sequencing steven-hyman yoshiki-sasai

Harvard chemist teases out why drugs work (or don’t)

Assistant Professor Brian Liau of the Chemistry and Chemical Biology Department has answered the question of why some new drugs for acute myeloid leukemia don’t work by combining CRISPR gene editing with small-molecule inhibitor treatments in a technique he calls CRISPR-suppressor scanning.

Caitlin McDermott-Murphy | May 6, 2019 | harvard
~7 mins   

Tags: science-technology acute-myeloid-leukemia aml brian-liau chemistry chemistry-and-chemical-biology crispr leukemia nature-chemical-biology

Brigham, Broad Institute researchers ID molecules that rein in CRISPR systems

Scientists have identified the first chemical compounds able to inhibit and regulate CRISPR systems, which could ultimately make CRISPR gene-editing technologies more precise, efficient, and safe.

Karen Zusi | May 2, 2019 | harvard
~5 mins   

Tags: science-technology amit-choudhary brigham-and-womens-hospital broad-institute cas-enzymes cell crispr gene-editing

Page 1 of 1