An emerging view of RNA transcription and splicing

Whitehead Institute scientists find chemical modification contributes to trafficking between non-membrane-bound compartments that control gene expression.

Nicole Davis | Whitehead Institute | Aug. 9, 2019 | mit
~6 mins   

Tags: whitehead-institute biology school-of-science genetics research rna dna


A new way to block unwanted genetic transfer

Researchers identify a strategy to prevent mobile genetic elements from breaching the bacterial cell wall.

Raleigh McElvery | Department of Biology | Aug. 5, 2019 | mit
~9 mins   

Tags: biology school-of-science bacteria health microbes research national-institutes-of-health-nih dna genetics

Speeding up drug discovery for brain diseases

Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder.

Nicole Davis | July 31, 2019 | mit
~6 mins   

Tags: whitehead-institute picower-institute school-of-science behavior biology brain-and-cognitive-sciences crispr development disease genetics mental-health national-institutes-of-health-nih pharmaceuticals research proteins drug-development

Neuroscientists identify brain region linked to altered social interactions in autism model

In a mouse model, restoring activity of a specific forebrain region reverses social traits associated with autism.

Sabbi Lall | McGovern Institute for Brain Research | July 26, 2019 | mit
~4 mins   

Tags: mcgovern-institute broad-institute brain-and-cognitive-sciences school-of-science autism genetics research neuroscience

Uncovering the riches of traditional global medicine

Researchers solve how the kava plant produces its pain-relieving and anti-anxiety molecules, demonstrate an extensible method to scale and optimize production.

Greta Friar | Whitehead Institute | July 23, 2019 | mit
~7 mins   

Tags: whitehead-institute biology school-of-science evolution genetics mental-health national-science-foundation-nsf research health plants

Genetic study takes research on sex differences to new heights

Differences in male and female gene expression, including those contributing to height differences, found throughout the body in humans and other mammals.

Greta Friar | Whitehead Institute | July 18, 2019 | mit
~8 mins   

Tags: whitehead-institute school-of-science biology evolution genetics national-institutes-of-health-nih research animals

New CRISPR platform expands RNA editing capabilities

The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible.

Sabbi Lall | McGovern Institute for Brain Research | July 11, 2019 | mit
~6 mins   

Tags: mcgovern-institute broad-institute brain-and-cognitive-sciences biological-engineering school-of-science crispr school-of-engineering rna dna genetics research

New gene-editing system precisely inserts large DNA sequences into cellular DNA

Researchers identify and develop new CRISPR-associated transposase system for targeted integration of DNA, adding key capabilities to gene-editing technology.

Karen Zusi | Broad Institute | June 12, 2019 | mit
~7 mins   

Tags: research crispr genome-editing rna dna genetics broad-institute mcgovern-institute biological-engineering brain-and-cognitive-sciences school-of-science school-of-engineering

Keeping genetic engineering localized

Researchers are developing a so-called "daisy-chain" gene-drive system that provides controls for genetic engineering of certain populations.

Helen Knight | MIT Media Lab | April 2, 2019 | mit
~7 mins   

Tags: research genetics evolution disease genetic-engineering ethics media-lab school-of-architecture-and-planning broad-institute crispr

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