(a-N-acetylneuraminyl-2,3-b-galactosyl-1,3)-N-acetyl-galactosaminide_6-a-sialyltransferase

α-<i>N</i>-Acetylneuraminyl-2,3-b-galactosyl-1,3-<i>N</i>-acetyl-galactosaminide 6-α-sialyltransferase

α-N-Acetylneuraminyl-2,3-b-galactosyl-1,3-N-acetyl-galactosaminide 6-α-sialyltransferase

Class of enzymes

α-N-Acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-α-sialyltransferase (EC 2.4.99.7, sialyltransferase, cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase, alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase, SIAT7, ST6GALNAC, (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase, CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase) is an enzyme with systematic name CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase.[1] This enzyme catalyses the following chemical reaction

CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R
Quick Facts α-N-Acetylneuraminyl-2,3-b-galactosyl-1,3-N-acetyl-galactosaminide 6-α-sialyltransferase, Identifiers ...

This enzyme attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure, where R may be protein or p-nitrophenol.

References

  1. [1]
    Bergh ML, Hooghwinkel GJ, van den Eijnden DH (June 1983). "Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver". The Journal of Biological Chemistry. 258 (12): 7430–6. PMID 6190802.
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