1,2-distearoyl-sn-glycero-3-phosphocholine

Distearoylphosphatidylcholine

Distearoylphosphatidylcholine

Chemical compound

Distearoylphosphatidylcholine is a phosphatidylcholine, a kind of phospholipid. It is a natural constituent of cell membranes, eg. soybean phosphatidylcholines are mostly different 18-carbon phosphatidylcholines (including minority of saturated DSPC), and their hydrogenation results in 85% DSPC.[1] It can be used to prepare lipid nanoparticles which are used in mRNA vaccines,[2][3] In particular, it forms part of the drug delivery system for the Moderna and Pfizer COVID-19 vaccines.[4][5]

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See also

Moderna COVID-19 vaccine nanoparticle ingredients
Others

References

  1. [1]
    van Hoogevest P, Wendel A (2014). "The use of natural and synthetic phospholipids as pharmaceutical excipients". The European Journal of Lipid Science and Technology. 116 (9): 1088–1107. doi:10.1002/ejlt.201400219. PMC 4207189. PMID 25400504.
  2. [2]
    Puri A, Loomis K, Smith B, Lee JH, Yavlovich A, Heldman E, Blumenthal R (2009). "Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic". Critical Reviews in Therapeutic Drug Carrier Systems. 26 (6): 523–80. doi:10.1615/critrevtherdrugcarriersyst.v26.i6.10. PMC 2885142. PMID 20402623.
  3. [3]
    Salvatori G, Luberto L, and Marra E (2020). "SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines". Journal of Translational Medicine. 18 (1): 222. doi:10.1186/s12967-020-02392-y. PMC 7268185. PMID 32493510.
  4. [4]
    "Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older" (PDF). Centers for Disease Control and Prevention (CDC).
  5. [5]
    "Pfizer-BioNTech COVID-19 Vaccine EUA Fact Sheet for Recipients and Caregivers". Food and Drug Administration (FDA). 29 June 2022.
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