AD 100 (C) was a leap year starting on Wednesday (link will display the full calendar) of the Julian calendar. In the Roman Empire, it was sometimes referred to as year 853 ab urbe condita, i.e., 853 years since the founding of Rome in 753 B.C. The denomination AD 100 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.

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This year saw Pacores, the last king of the Indo-Parthian Kingdom, ascend to the throne. In the Americas, the Moche culture developed around this time, and Teotihuacan, a major city at the centre of modern-day Mexico, reached a population of around 60,000-80,000.

• Fa Zhen (or Gaoqing), Chinese scholar (d. 188)
• Faustina the Elder, Roman empress
• Justin Martyr, Christian apologist and saint (approximate date)
• Marcus Cornelius Fronto, Roman grammarian, rhetorician and advocate (d. 170)
• Ptolemy, Greek astrologer, astronomer, geographer and mathematician (d. 170)
• Quintus Junius Rusticus, Roman teacher and politician (approximate date)
• Quintus Tineius Sacerdos Clemens, Roman politician (approximate date)

• Agrippa II, Jewish king of Judea (b. AD 27)
• Apollonius of Tyana, Greek philosopher (b. AD 15)
• Josephus, Jewish historian and writer (b. AD 37)
• John the Apostle of Jesus Christ (b. AD 6)
• Wang Chong, Chinese philosopher (b. AD 27)