Events from the year 1527 in art.

• c. May 6 - The engraver Jacopo Caraglio flees to Venice from the Sack of Rome
• Marcantonio Raimondi publishes the second edition of his erotic engravings I Modi in Rome (accompanied by Aretino's Sonetti lussuriosi); like the first they are suppressed by Pope Clement VII
• Pieter Coecke van Aelst enters the Antwerp Guild of painters
• John Browne becomes the first Serjeant Painter at the English Court

• Hans Holbein the Younger – Sir Thomas More
• Lorenzo Lotto – Man with a Golden Paw
• Stanisław Samostrzelnik – Book of hours of Queen Bona Sforza and Prayer book of Krzysztof Szydłowiecki (approximate date decorations completed)
• Lucas van Leyden – The Last Judgement (triptych, Museum De Lakenhal, Leiden, 1526 or 1527)

• November 18 - Luca Cambiasi, Italian painter (died 1585)^[1]
• date unknown
  • Michelangelo Aliprandi, Italian painter, pupil of Veronese (died 1595)
  • Giuseppe Arcimboldo, Italian painter (died 1593)^[2]
• probable
  • Pellegrino Tibaldi, Italian mannerist architect, sculptor, and mural painter (died 1596)^[3]
  • Alexander Colyn (born 1527/1529), Flemish sculptor (died 1612)

• May - Cristoforo Solari, Italian sculptor and architect (born 1460)
• June 28 - Bernardo de' Rossi, Italian bishop and patron of the arts (born 1468)
• date unknown
  • Lorenzo Allegri, Italian painter (born unknown)
  • Raffaellino del Garbo, Florentine painter of the early-Renaissance (born c. 1466)
  • Cornelis Engebrechtsz., Dutch painter, the first notable painter from Leiden (born 1462)
  • Cristoforo Foppa, Italian goldsmith, sculptor, and die sinker (born 1445)
  • Jan Mertens the Younger, South Netherlandish painter (born unknown)
  • Domenico Puligo, painter from Florence (born 1492)
  • Jan van Dornicke, South Netherlandish painter (born 1470)
  • Jan Wellens de Cock, Flemish painter and draughtsman of the Northern Renaissance (born 1480)^[4]