This article contains information about the literary events and publications of 1569.

• September 28 – First complete printed Bible in Spanish translation (La Biblia, known from its title-page illustration as "Biblia del Oso" ("Bible of the Bear")), made by Casiodoro de Reina, published in Basel.^[1][2]
• undated – Performance of the 14th-century York Mystery Plays in England is suppressed.

• January 2 – Heribert Rosweyde, Netherlandish hagiographer (died 1629)
• April 16 – Sir John Davies, English poet (died 1626)
• c. December? – Henry Ainsworth, English theologian (died 1622)
• Unknown dates
  • Guillén de Castro y Bellvis, Spanish dramatist (died 1631)
  • Heo Gyun, Korean politician, scholar, and writer (died 1618)
  • Emilia Lanier, English poet (died 1645)
  • Hieronymus Medices, Italian philosopher and editor of work of Thomas Aquinas
  • Piotr Zbylitowski, Polish poet and satirist (died 1649)
• probable – Barnabe Barnes, English poet and dramatist (baptised 1571; died 1609)

• January 20 – Myles Coverdale, English Bible translator (born c. 1488)^[3]
• May 10 – Saint John of Avila, Spanish preacher and author (born 1500)
• September 5 – Bernardo Tasso, Italian poet (born 1493)^[4]
• September/October – Mikołaj Rej, Polish poet and author (born 1505)
• November 29 – António Ferreira, Portuguese poet (born 1528)
• Unknown date – Georg Pictorius, German physician and author (born c. 1500)