The 1650s BC was a decade lasting from January 1, 1659 BC to December 31, 1650 BC.

• c. 1655 BC—Tan-Uli, the ruler of the Elamite Empire, dies.
• c. 1650 BC—Greeks start to live in Mycenae.
• c. 1650 BC—Middle Kingdom ends in Ancient Egypt (other date is 1674 BC).
• c. 1650 BC—Second Intermediate Period starts in Ancient Egypt (other date is 1674 BC).
• c. 1650 BC – "Flotilla" fresco, from Room 5 of West House, Akrotiri (prehistoric city), Thera, is made. Second Palace period. It is now kept in National Archaeological Museum, Athens.
• Egypt—Start of Seventeenth Dynasty.
• c. 1650 BC—Between Rapperswil and Hurden, on the so-called Seedamm, a first wooden bridge was constructed on Lake Zürich in Switzerland
• c. 1650 BC—The last Woolly mammoths die on Wrangel Island, rendering the species extinct.
• c. 1650 BC—The Rhind Mathematical Papyrus is produced.^[1]
• c. 1650 BC—Beginning of construction of 900-acre Poverty Point settlement earthworks (now northern Louisiana) by NA hunter-gatherers.