This article contains information about the literary events and publications of 1750.

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• March – The Rambler is founded by Edward Cave; it lasts for 208 issues, and is mostly written by Samuel Johnson.^[1]
• March 5 – Shakespeare's Richard II (in Colley Cibber's version) is presented at their theatre on Nassau Street (Manhattan) by Walter Murray and Thomas Kean,^[2] the earliest known significant professional performance of Shakespeare in North America.
• unknown dates
  • Weekly meetings for contributors to the Encyclopédie begin, at the salon of Baron d'Holbach.
  • Jean-Jacques Rousseau wins the prize of the Academy of Dijon for his Discourse on the Arts and Sciences.
  • London theatres wage "the Romeo and Juliet war" – competing productions appear with David Garrick and Anne Bellamy at the Theatre Royal, Drury Lane and with Spranger Barry and Susannah Cibber at the Royal Opera House in Covent Garden.
  • Old Orchard Street Theatre opens in Bath (England) under the management of John Palmer, with a performance of Shakespeare's Henry IV, Part 2.^[3]
  • Carlo Goldoni commits himself to writing a comedy for each week of the 1750–1751 seasons at Gerolamo Medebach's Teatro San Angelo in Venice – 16 plays.^[4]
• After taking an M.D. at Aberdeen, Tobias Smollett travels in France, collecting material for The Adventures of Peregrine Pickle.

• January 7 – Robert Anderson, Scottish critic (died 1803)
• June 13 – James Burney, English rear-admiral and naval writer (died 1821)
• September 5 – Robert Fergusson, Scottish poet writing in Braid Scots (died 1774)
• October 21 – Juraj Fándly, Slovak non-fiction writer, entomologist and priest (died 1811)
• October 31 – Leonor de Almeida Portugal, 4th Marquise of Alorna, Portuguese noblewoman, painter, and poet (died 1839)^[6]
• unknown date – Henrietta Maria Bowdler, English author and expurgator (died 1830)

• February 8 – Aaron Hill, English dramatist (born 1685)
• May 3 – John Willison, Scottish Christian writer (born 1680)
• June 15 – Marguerite De Launay, Baronne Staal, French writer (born 1684)
• November 11 – Apostolo Zeno, Venetian poet and journalist (born 1668)^[7]
• November 18 – Susanna Highmore, English poet (born 1690)