This is a list of music related events in 1768.

• Johann Christian Bach gives the first ever solo piano performance, in London on an instrument by Johannes Zumpe.^[1]
• Wolfgang Amadeus Mozart and his family are resident in Vienna until December.
• Antonio Sacchini returns to Venice to become director of the Conservatorio dell'Ospadeletto.
• Giuseppe Tartini suffers a stroke.
• Michael Haydn marries Maria Magdalena Lipp, a singer and the daughter of the court organist.

• "The Liberty Song", with words by John Dickinson – considered the first American patriotic song. He used the music to the traditional British song, Hearts of Oak.

• Johann Adolf Hasse – Piramo e Tisbe
• Joseph Haydn – Lo speziale
• Niccolò Jommelli
  • Fetonte
  • La schiava liberata
• Wolfgang Amadeus Mozart
  • Bastien und Bastienne, K. 50/46b (his first published opera)
  • La finta semplice, K.51/46a
• Giovanni Paisiello – Olimpia
• Antonio Zingarelli – I quattro pazzi

• Luigi Boccherini
  • Cello Concerto in D Major
  • Cello Sonata in C major, G.6
  • 6 Violin Sonatas, G.25-30, Op. 5
• Muzio Clementi – Sonata for Harpsichord in G major
• John Garth – Six Sonatas for the Harpsichord, piano forte and organ with accompanyments for two violins and a violoncello, Op. 2
• Pietro Alessandro Guglielmi – 6 Harpsichord Quartets, Op. 1
• Joseph Haydn
  • Applausus
  • 6 String Trios, Op. 5
  • Symphony No.49 in F minor, Hob.I:49 "La passione", "Il quakuo di bel'humore"
• Michael Haydn – Missa sancti Francisci Seraphici, MH 119
• Wolfgang Amadeus Mozart – Symphonies No. 7 and No. 8
• Friedrich Schwindl – 6 Trio Sonatas, Op. 5

• William Hayes – Anecdotes of the 5 Music-Meetings
• Johann Caspar Heck – A Complete System of Harmony
• Gabriele Leone Méthode raisonnée pour passer du Violon à la Mandoline (Rational method for migrating from the violin to the mandolin)
• Jean-Jacques Rousseau – Dictionnaire de musique
• Francisco Inácio Solano – Nova arte, e breve compendio de musica

• January 16 – Carl Andreas Göpfert, German composer (died 1818)
• March 12 – Carolus Antonius Fodor, composer
• April 7 – Karl Theodor Toeschi, composer
• July 6 – Johann Georg Heinrich Backofen, composer and clarinetist (died 1830)
• September 1 – Carl Bernhard Wessely, composer
• September 12 – Benjamin Carr, composer
• September 14 – Georg Johann Schinn, composer
• September 21 – Louis-Emmanuel Jadin, composer, pianist and harpsichordist (c. 1863)
• November 24 – Jean-Engelbert Pauwels, composer
• December 6 – Johann Baptist Henneberg, composer
• date unknown
  • Gaetano Crivelli, operatic tenor (d. 1836)
  • Margarethe Danzi, collaborator and composer (died 1800)

• January 1 – Jean-Laurent Krafft, composer
• January 28 – John Wainwright, composer
• March 3 – Nicola Porpora, composer
• March 14 – Vigilio Blasio Faitello, composer
• July 6 – Johann Conrad Beissel, composer
• July 11 – José Melchior de Nebra Blascu, composer
• August 21 (buried) – William Walond, English composer (born 1719)
• October 28 – Michel Blavet, flautist and composer
• October 31 – Francesco Maria Veracini, violinist and composer
• November 1 – Pierre van Maldere, composer
• probable – Domenico Gallo, composer and musician (born 1730)