The 1910 college football season had no clear-cut champion, with the Official NCAA Division I Football Records Book listing Harvard and Pittsburgh as having been retrospectively selected national champions, by four "major selectors" in about 1927, 1947, 1970 and 1980.^[1] Harvard claims a national championship for the 1910 season.

Rule changes were made prior to the 1910 season to permit more use of the forward pass, with complicated limitations:^[2]

• The only eligible receivers were the two ends, who could catch a pass no more than 20 yards beyond the line of scrimmage, and could not be interfered with until the ball was caught.
• A legal pass could not be thrown unless the quarterback was at least 5 yards behind the line of scrimmage and the rest of the players, except the two ends, were at least 1 yard behind the scrimmage line.
• On kickoffs and punts, the kicking team's players could not be touched until they had advanced 20 yards
• Flying tackles were outlawed, and "the man making a tackle must have at least one foot on the ground".
• The ballcarrier could no longer be aided in any way by his teammates.

Other rules in 1910 were:

• Field 110 yards in length
• Kickoff made from midfield
• Three downs to gain ten yards
• Touchdown worth 5 points
• Field goal worth 3 points
• Game time based on agreement of the teams, not to exceed two 45 minute halves.^[3]

The season ran from September 24 until Thanksgiving Day (November 24).^[4] Prior to Thanksgiving, the season's death toll was 22; the previous season's was thirty.^[5]

• The Colorado Faculty Athletic Conference (CFAC) changed its name to the Rocky Mountain Faculty Athletic Conference (RMFAC, now just the Rocky Mountain Athletic Conference) in 1910 after expanding into Utah.