The 1916 Berwick-upon-Tweed by-election was held on 16 August 1916. The by-election was held due to the elevation to the peerage of the incumbent Liberal MP, Sir Edward Grey.

It was won by the Liberal candidate Sir Francis Blake.^[1] Blake was unopposed by Conservative or Labour candidates due to a war time electoral truce where the three main parties would not put up candidates against one another. This meant that Blake was sometimes referred to as a "Coalitionist".^[2] The unsuccessful candidate, Dr Arthur Turnbull, stood as an Independent, though one source has described him as an Independent Liberal.^[3]