1980–81 Albanian Cup (Albanian: Kupa e Shqipërisë) was the twenty-ninth season of Albania's annual cup competition. It began in August 1980 with the First Round and ended in June 1981 with the Final matches. The winners of the competition qualified for the 1981-82 first round of the UEFA Cup. Partizani were the defending champions, having won their eleventh Albanian Cup last season. The cup was won by Vllaznia.^[1]

The rounds were played in a two-legged format similar to those of European competitions. If the aggregated score was tied after both games, the team with the higher number of away goals advanced. If the number of away goals was equal in both games, the match was decided by extra time and a penalty shootout, if necessary.

Games were played on August & September 1980*

• Results unknown

In this round entered the 16 winners from the previous round. First and second legs were played in January 1981.

In this round entered the 8 winners from the previous round.

In this round entered the four winners from the previous round.

In this round entered the two winners from the previous round.

First leg

More information Besa, 2–1 ...

Besa	2–1	Vllaznia
Shtini 26' Mullaliu 76'		Gruda 39'

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10 June 1981

Besa Stadium, Kavajë

Second leg

More information Vllaznia, 5–1 ...

Vllaznia	5–1	Besa
Luçi ??' Hafizi ??', 82' Gruda 78' Duraj 86'		Shtini 43'

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14 June 1981

Vojo Kushi Stadium, Shkodër