The 1981 Cleveland Browns season was the team's 32nd season with the National Football League. In a highly disappointing season filled with a number of key injuries at different stretches during the campaign, the Browns finished the year with five straight defeats, their longest losing streak since 1975, and dropped seven of their final eight games. By contrast, in 1980, the Browns enjoyed a five-game winning streak.

The Browns had a similar kind of season in 1981—eight of the games were decided by six points or less, and five were decided by three points or less. Sipe threw more interceptions (25) than TDs (17), his completion rate fell to just over 55 percent and his quarterback rating plummeted to 68.2. FB Mike Pruitt rushed for more than 1,000 yards (1,103) for the third straight year in 1981, and caught 63 passes for the second season in a row. Tight end Ozzie Newsome set a team record (since broken) for receptions with 69 and had the second-most receiving yards in Browns history at the time with 1,002.

HB Greg Pruitt established a personal best with 65 catches.^[1]

Ironically, through 2023 the 1981 Browns are the only team since the AFL-NFL merger in 1970 to have beaten both eventual Super Bowl participants, the Super Bowl champion San Francisco 49ers and the AFC Champion Cincinnati Bengals, while finishing with a losing record.