The following is the 1981–82 network television schedule for the three major English language commercial broadcast networks in the United States. The schedule covers primetime hours from September 1981 through August 1982. The schedule is followed by a list per network of returning series, new series, and series cancelled after the 1980–81 season. All times are Eastern and Pacific, with certain exceptions, such as Monday Night Football.

New series are highlighted in bold.

Each of the 30 highest-rated shows is listed with its rank and rating as determined by Nielsen Media Research.^[1]

  Yellow indicates the programs in the top 10 for the season.

  Cyan indicates the programs in the top 20 for the season.

  Magenta indicates the programs in the top 30 for the season.

Note: A Writers Guild of America strike hindered the ability to start airing shows in a timely manner. The shows in the schedule were the first to air new episodes in their respective time periods as they premiered between September and early December. The debut month for each new series that had been intended for a fall premiere is noted as to when it actually appeared.

PBS, the Public Broadcasting Service, was in operation but the schedule was set by each local station.

Note : On NBC, The Powers of Matthew Star was supposed to have aired 7-8 p.m., starting December 6, but production difficulties forced its delay into the next season.

Note: On ABC, Joanie Loves Chachi premiered March 23, 1982, at 8:30 pm, in place of Laverne & Shirley. On CBS, Q.E.D. ran for 6 weeks at 8pm, from March 23 to April 27.^[2]

NOTE: The only episode of the sitcom Cass Malloy aired on CBS from 8:30 to 9:00 p.m. Eastern Time on July 21, 1982. Although not picked up as a regular series, it served as the pilot for the 1987–1989 syndicated sitcom She's the Sheriff.

Note: On CBS, Nurse aired at 9-10 p.m. and Knots Landing at 10-11 p.m., both in September and October. On ABC, Bosom Buddies aired at 9-9:30 p.m. in October.

(*) Also known as It's a Living.

Note: On ABC, Maggie was replaced by Open All Night, effective November 28; King's Crossing, which was supposed to have aired 8-9 p.m., was delayed until January, 1982, as an indirect result of the Writers Guild of America strike. On NBC, The Devlin Connection was supposed to have aired at 10:00 p.m., but Rock Hudson's heart surgery forced the delay into next season.^[3]