The 1985 Major League Baseball season ended with the Kansas City Royals defeating the St. Louis Cardinals in the seventh game of the I-70 World Series. Bret Saberhagen, the regular season Cy Young Award winner, was named MVP of the Series. The National League won the All-Star Game for the second straight year.

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The League Championship Series playoffs were expanded to a best-of-seven format beginning this year,^[1] and both leagues ended up settling their pennant winners in more than five games, with the Royals beating the Toronto Blue Jays in seven games, and the Cardinals beating the Los Angeles Dodgers in six games. This was the first full season for Peter Ueberroth as commissioner.

There was a brief interruption during the regular season. The 1985 Major League Baseball strike occurred August 6 and 7, lasting only two days. The 25 cancelled games were for the most part made up later on in the season.

• Baseball Hall of Fame
  • Lou Brock
  • Enos Slaughter
  • Arky Vaughan
  • Hoyt Wilhelm

• All-Star Game, July 16 at the Metrodome in Minneapolis: National League, 6–1; LaMarr Hoyt, MVP.^[2]

• On August 4, at Yankee Stadium, Tom Seaver won his 300th game as a member of the Chicago White Sox.^[3]
• On August 4, at Anaheim Stadium, Rod Carew got his 3000th hit as a member of the California Angels.^[3]
• On September 11, Pete Rose reached 4,192 hits, breaking Ty Cobb's all-time major league career hits record.^[4]
• On October 6, Phil Niekro won his 300th game and became the oldest pitcher (age 46) to record a shutout as a member of the New York Yankees.^[5]