5 March

Some of the opposition groups had already distributed pamphlets to the local population, feeding anti-Saddam sentiment to the people. It was also reported that a number of these opposition groups consisted of former regular Iraqi Army soldiers who had served in Kuwait during the Persian Gulf War. Earlier that day, soldiers who were returning from the front arrived in Karbala.

The revolt began at 2:30 PM when youths began to ride through the streets with weapons, attacking government buildings and loyalist soldiers. This action encouraged the people to come out of their homes with light arms and knives, known as "white weapons," and join in the attack. Such weapons were supplemented with heavier weapons which were captured from Baath Party forces. The Holy Endowments administration building was the first to be sacked, followed by the sacking of several other buildings. The rebels also stormed the al-Husseini hospital and took over its wards. Many of the holy Shia shrines immediately became the main headquarters of the insurgents, the two main headquarters being the Shrines of Husayn ibn Ali and Al-Abbas ibn Ali.

Some of the local Baathist officials and some of the top security agents, including the chief of police and the deputy governer, were killed in brutal ways because they did not retreat in time. Many of their bodies were left lying in the streets and some of them were burned. On the loudspeakers which were located inside the Shia Shrines, insurgents called for prisoners to be brought to the Shrine of Abbas for execution. By morning, the city was under complete rebel control.

6–11 March

The insurgents hoped that Saddam's regime would not be able to quell the rebellion without air power. But issues had been provoked throughout the city, which was blocked by the coalition forces as a condition of the Gulf War ceasefire. However, US Forces did not prevent Saddam's forces from using overwhelming force to suppress the uprising. Karbala was subjected to severe artillery shelling and rebel holdouts were attacked with helicopter gunships, despite the official declaration of Iraqi no-fly zones.

The Iraqi Republican Guards encountered resistance as soon as they entered the city. As a result of the mostly-Sunni Republican Guards' resentment of the Shiites, it was said that the tanks bore placards which read , "No More Shia After Today." The main targets included the main Shia shrines and the al-Husseini hospital. At the hospital, doctors treated the wounded while people continually rushed into it in order to donate blood and medicine, despite the concentrated shelling from the loyalist forces which were located on the outskirts of the city. The rebels put up stiff resistance in defense of the hospital. Once the hospital fell, the army rounded up doctors and nurses and took them away for execution. Patients were thrown out of windows and reports surfaced of bulldozers burying bodies on the grounds of the hospital.

Throughout the counterattack, voices could be heard on loudspeakers which were located in the shrines of Abbas and Hussein, directing the insurgents to attack the Republican Guards. In the closing days of the uprising, the shrines were heavily damaged by artillery shells and rockets which were fired from helicopters. Many rebels and many civilians who supported them barricaded themselves in the buildings. In video recordings of the uprising, the people are dancing in euphoria and they are also requesting aid from America and Iran, aid which never came. Once the loyalist forces surrounded the shrine, the leader of the assault and a henchman of Saddam, Kamal Hussein Majid, stood on a tank and shouted: "Your name is Hussein and so is mine. Let us see who is stronger now." He then gave the order to open fire on the shrine.^[2] After blowing down the doors of the shrine, the Guards rushed in and killed the majority of the people who were inside the shrine with automatic weapons fire.

Once it was in control of the city, the army encircled each district of it and looked for young men. At first, the soldiers shot whoever they saw. After a day or so, they arrested every male who was over the age of 15. Shia clerics who were seen walking on the streets were rounded up and never seen again. Dead bodies were mined and people were not allowed to remove them from the streets. Helicopter gunships which were located on the outskirts of the city reportedly strafed civilians while they were fleeing from the city.

19 March

Soldiers took vengeance on rebels and civilians who had not fled. Moving from district to district, they rounded up young men who they suspected of being rebels, transported them to stadiums and executed some of them. Others were reportedly sent to a large detention facility outside Baghdad. Such marks indicated that the uprising was officially suppressed.^{[citation needed]}