2,3-diaminopropionate

2,3-Diaminopropionic acid

2,3-Diaminopropionic acid

Chemical compound

2,3-Diaminopropionic acid (2,3-diaminopropionate, Dpr)[1] is a non-proteinogenic amino acid found in certain secondary metabolites, including zwittermicin A[2] and tuberactinomycin.[3]

Quick Facts Names, Identifiers ...
Not to be confused with Diaminopimelic acid.

Biosynthesis

2,3-Diaminopropionate is formed by the pyridoxal phosphate (PLP) mediated amination of serine.

Biosynthesis of l-2,3 Diaminopropionate

References

  1. [1]
    Frenkel-Pinter M, Haynes JW, C M, Petrov AS, Burcar BT, Krishnamurthy R, et al. (August 2019). "Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions". Proceedings of the National Academy of Sciences of the United States of America. 116 (33): 16338–16346. doi:10.1073/pnas.1904849116. PMC 6697887. PMID 31358633.
  2. [2]
    Rogers EW, Molinski TF (February 2007). "Asymmetric synthesis of diastereomeric diaminoheptanetetraols. A proposal for the configuration of (+)-zwittermicin a". Organic Letters. 9 (3): 437–40. doi:10.1021/ol062804a. PMC 2729442. PMID 17249781.
  3. [3]
    Thomas MG, Chan YA, Ozanick SG (September 2003). "Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster". Antimicrobial Agents and Chemotherapy. 47 (9): 2823–30. doi:10.1128/AAC.47.9.2823-2830.2003. PMC 182626. PMID 12936980.
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