The 2010–11 Maltese FA Trophy was the 73rd season since its establishment. It will feature 21 teams from the Maltese Premier League, the First Division and the champions of the Gozo First Division. The competition began on 10 November 2010 and ended 22 May 2011 with the Final from Ta' Qali Stadium. The defending champions are Valletta, having won their 12th Maltese Cup last season and first since 2001. The winner will qualify to the second qualifying round of the 2011–12 UEFA Europa League.

Valletta were the defending champions, but lost in the Final to Floriana.

Matches will begin on 10 November 2010 and conclude with the final on 22 May 2011.^[1] For the second straight year, four teams will receive a bye directly into the quarterfinals.

Entering this round were two clubs from the Maltese First Division. This match took place on 10 November 2010.

Entering this round was the winner from the preliminary round along with the six Maltese Premier League clubs which finished last season between 5th and 10th place in the league, the remaining eight clubs from the First Division and the reigning Gozo First Division champions. These matches took place from 12 to 14 November 2010.

Entering this round were the eight winners from the first round. These matches took place on 19 January 2011.

Entering this round were the four winners from the second round along with the best four clubs from last year's Premier League competition.

Sliema Wanderers v Birkirkara

19 March 2011	Sliema Wanderers	3–3 (a.e.t.) (1–3 p)	Birkirkara	Ta' Qali
14:00 CET	Triganza 4', 69' Barbara 113'		Vukanac 45' Babatunde 55' Galea 118'	Stadium: Ta' Qali National Stadium

Valletta v Hibernians

19 March 2011	Valletta	1–0 (a.e.t.)	Hibernians	Ta' Qali
16:00 CET	Denni 99'			Stadium: Ta' Qali National Stadium

Vittoriosa Stars v Tarxien Rainbows

20 March 2011	Vittoriosa Stars	2–4	Tarxien Rainbows	Paola
14:00 CET	Luis 26' (pen.) Jorge 90' (pen.)		Ricardo Costa 45' (pen.), 73' Everton  54'  90+2' Critien 63' Bueno 80'	Stadium: Hibernians Ground

Qormi v Floriana

20 March 2011	Qormi	1–1 (a.e.t.) (3–5 p)	Floriana	Paola
16:00 CET	Vandelannoite 71' Vandelannoite  72'		Borg 58' Saïdi  97'	Stadium: Hibernians Ground

Entering this round were the four winners from the Quarterfinals.

Tarxien Rainbows v Valletta

14 May 2011	Tarxien Rainbows	0–1 (a.e.t.)	Valletta	Ta' Qali
17:00 CET	Mintoff  120+2'		Denni 116'	Stadium: Ta' Qali National Stadium

Birkirkara v Floriana

15 May 2011	Birkirkara	1–2	Floriana	Ta' Qali
17:00 CET	Cilia 66' (pen.)		Caruana 23' Farrugia 60'	Stadium: Ta' Qali National Stadium

Entering this round were the two winners from the Semifinals.

Valletta v Floriana

22 May 2011	Valletta	0–1	Floriana	Ta' Qali
17:00 CET			Woods 89'	Stadium: Ta' Qali National Stadium Attendance: 8,405 Referee: Paul Caruana