The 2010 FIFA World Cup CONCACAF–CONMEBOL qualification play-off were a series of two-legged home-and-away ties between the fourth-placed team of the CONCACAF qualifying tournament, Costa Rica, and the fifth-placed team from the South American qualifying tournament, Uruguay.

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2010 FIFA World Cup qualification
(CONCACAF–CONMEBOL play-off)

Event	2010 FIFA World Cup qualification
Costa Rica Uruguay 1 2
on aggregate
First leg
Costa Rica Uruguay 0 1
Date	14 November 2009
Venue	Estadio Ricardo Saprissa Aymá, San José
Referee	Alberto Undiano Mallenco (Spain)
Attendance	19,500
Weather	Calm 21 °C (70 °F)[1]
Second leg
Uruguay Costa Rica 1 1
Date	18 November 2009
Venue	Estadio Centenario, Montevideo
Referee	Massimo Busacca (Switzerland)
Attendance	62,150
Weather	Party cloudy 20 °C (68 °F)[2]

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The games were played on 14 and 18 November 2009. In the first leg, held in San José, Uruguay beat Costa Rica 1–0, while in the second leg played at Estadio Centenario in Montevideo, both teams tied 1–1. Uruguay won the series 2–1 on aggregate and qualified for the 2010 World Cup.

It was the third consecutive FIFA World Cup play-off that Uruguay has participated in after 3–1 on aggregate win over Australia for Korea/Japan 2002 and losing to Australia 4–2 on penalties for Germany 2006.

The draw for the order in which the two matches would be played was held on 2 June 2009 during the FIFA Congress in Nassau, The Bahamas.^[3]