This is a list of notable events in Latin music (music from Spanish- and Portuguese-speaking areas of Latin America, Europe, and the United States) that took place in 2010.

• November 11 – The 11th Annual Latin Grammy Awards are held at the Mandalay Bay Events Center in Las Vegas, Nevada:^[1]
  • Mexican pop group Camila wins the Latin Grammy Award for Record of the Year for "Mientes" while Mario Domm and Monica Velez won the Latin Grammy Award for Song of the Year for the song.
  • A Son de Guerra by Dominican singer and songwriter Juan Luis Guerra and his group 4.40 wins the Latin Grammy Award for Album of the Year.
  • Alex Cuba wins Best New Artist.
  • Spanish tenor Plácido Domingo is honored as the Person of the Year by the Latin Recording Academy.

• List of Hot 100 number-one singles of 2010 (Brazil)
• List of number-one albums of 2010 (Mexico)
• List of number-one albums of 2010 (Spain)
• List of number-one singles of 2010 (Spain)
• List of number-one Billboard Latin Albums from the 2010s
• List of number-one Billboard Top Latin Songs of 2010

• 2010 Premio Lo Nuestro
• 2010 Billboard Latin Music Awards
• 2010 Latin Grammy Awards
• 2010 Tejano Music Awards

• January 4 – Sandro de América, 64, Argentinian singer, complications from heart and lung transplant surgery.^[4]
• February 18 – Ariel Ramírez, 88, Argentine composer and pianist, pneumonia.^[5]
• February 28 – Jorge Villamil, 80, Colombian composer, complications from diabetes.^[6]
• March 4 – Johnny Alf, 80, Brazilian singer and composer, prostate cancer.^[7]
• March 9 – Tato Luzardo, 65, Spanish music executive^[8]
• April 7 – Graciela, 94, Cuban singer, renal and pulmonary failure.^[9]
• May 5 – Lucho Barrios, 76, Peruvian bolero singer.^[10]
• May 7 – Francisco Aguabella, 84, Cuban-born American jazz percussionist, cancer.^[11]
• May 17 – Héctor Meneses, 68, Mexican singer and songwriter^[12]
• June 8 – Armando Zabaleta, 83, Colombian songwriter^[13]
• July 12:
  • Olga Guillot, 87, Cuban singer, infarction.^[14]
  • Paulo Moura, 77, Brazilian saxophonist and clarinetist, lymphoma.^[15]
• August 7 – Roberto Cantoral, 75, Mexican composer, heart attack.^[16]
• August 13 – Steve Jordan, 71, American accordionist, complications from liver cancer.^[17]
• August 19 – José Antonio Labordeta, 75, Spanish songwriter, professor, writer, presenter and politician.^[18]
• August 21 – Hugo Guerrero Marthineitz, 86, Peruvian journalist, commentator and radio host, cardiac arrest.^[19]*November 14 – Tony Moreno, 66, Cuban promoter and record label executive (MP Records)^[20]
• September 28 – Romina Yan, 36, Argentine actress (Chiquititas), cardiac arrest.^[21]
• November 26 – Mario Pacheco, 60, Spanish music producer and photographer.^[22]
• December 13 – Enrique Morente, 67, Spanish flamenco singer.^[23]
• December 23 – Toninho Spessoto [pt], 52, Brazilian entertainment journalist^[24]
• December 28 – Zeferino Nandayapa, 79, Mexican classical marimbist, injuries from a fall.^[25]