This is a list of events that happened in 2010 in Mexico. The article also lists the most important political leaders during the year at both federal and state levels.

• January 3 – Mexican police arrest alleged drug lord Carlos Beltrán Leyva in Culiacán, Sinaloa.^[3]
• January 12 – Mexican authorities report the capture of Teodoro García Simental, one of the country's most notorious drug lords, in a raid in La Paz, Baja California Sur.^[4]
• March 4 – A Mexico City law allowing same-sex marriages takes effect.^[5]
• March 19 – Jorge Antonio Mercado Alonso, 23, and Javier Francisco Arredondo Verdugo, 24, students at the Tecnológico de Monterrey are killed on the university campus in Nuevo León by the Mexican Army. Cuauhtémoc Antúnez, the military commander, accused them of drug trafficking, but a subsequent investigation proved that the soldiers altered the scene and planted weapons on the young men. Nine years later, on March 19, 2019, Olga Sánchez Cordero, Secretaria de Gobernación (Interior Secretary) apologized for the government's actions.^[6]
• March 30 – Ten children, youths and young adults between the ages of 8 and 21 are gunned down, presumably by drug traffickers, in the northern Mexican state of Durango.^[7]
• April 25 – Mexican Labour Party leader in Guerrero Rey Hernández dies after being shot at least seven times outside his home in Tlacoachistlahuaca.^[8]
• May 15 – Former Mexican presidential candidate Diego Fernández de Cevallos is abducted from one of his homes in Pedro Escobedo, Querétaro.^[9]
• May 31 – A mass grave containing between 20 and 25 bodies is found in an abandoned mine near Taxco, Guerrero, in Mexico.^[10]
• June 11 – 40 people are killed and at least four others are wounded in an attack by at least 30 gunmen in Chihuahua, Mexico.^[11]
• June 14 – At least 28 prisoners are killed in a clash between rival gangs in Sinaloa, Mexico.^[12]
• June 15 – Two trains collide in the northern Mexican state of Sinaloa resulting in the death of at least 13 people.^[13]
• June 16 – A shootout in the Mexican tourist town of Taxco leaves 15 dead.^[14]
• June 20 – A Bell 412 Mexican military helicopter crashes in Durango state in northern Mexico Saturday, killing all 11 people on board.^[15]
• June 28 – Rodolfo Torre Cantu, a leading candidate in a Mexican state election is assassinated near Ciudad Victoria.^[16] President of Mexico Felipe Calderón blamed drug cartels for the assassination.^[17]
• June 30 – 2010 Oaxaca earthquake: A 6.2-magnitude earthquake occurs in southern Mexico near the city of Pinotepa Nacional, shaking buildings as far away as Mexico City but not causing serious damage or casualties.^[18]
• July 4 – 2010 Mexican gubernatorial elections: Voters in 14 Mexican states vote to elect governors and mayors.^[19]
• July 18 – At least 17 people are killed and at least 10 others are wounded during a pre-dawn gun attack on a birthday party in Torreón, Coahuila state in Mexico, across the border from Texas.^[20]
• July 24 – A mass grave containing at least 50 tortured and burned corpses is unearthed east of Monterrey, Nuevo León, in Mexico.^[21]
• July 28 – Eight severed heads are discovered in four locations in the Mexican state of Durango.^[22]
• July 29 – The Mexican Army kills Sinaloa Cartel drug lord Ignacio Coronel Villarreal in Zapopan, Jalisco, during a raid.^[23]
• August 6 – At least 14 people are killed during a prison riot in Matamoros in the Mexican state of Tamaulipas.^[24]
• August 9 – Former President of Mexico Vicente Fox calls for the legalisation of drugs in Mexico.^[25]
• August 10 – The Supreme Court of Justice of the Nation rules same-sex marriages in Mexico City have to be recognised across Mexico.^[26]
• August 16 – At least 2 people are injured after a grenade explosion outside a Televisa television station in Monterrey, Nuevo León, Mexico.^[27]
• August 16 – The mayor of the Mexican town of Santiago, Nuevo León, Edelmiro Cavazos, is abducted.^[28]
• August 18 – The corpse of mayor Edelmiro Cavazos of the Mexican town of Santiago, Nuevo León, is found handcuffed and blindfolded after his abduction on Sunday night.^[29]
• August 20 – Six police officers in Mexico are arrested and accused of participating in the kidnap and murder of Mayor Edelmiro Cavazos.^[30]
• August 23 – Jimena Navarrete, representing Mexico, wins Miss Universe 2010.^[31]
• August 25 – Mexican Naval Infantry find 72 corpses at a remote ranch in San Fernando, Tamaulipas, near the border with the U.S. state of Texas. The victims were economic migrants from Central America and South America believed to be murdered by a drug cartel.^[32]
• August 27 – Two bombs explode in the Mexican city of Ciudad Victoria, the capital of Tamaulipas, outside the municipal police station and the Televisa television station.^[33]
• August 29 – Unidentified gunmen assassinate Marco Antonio Leal Garcia, the mayor of the small town of Hidalgo in Tamaulipas, Mexico.^[34]
• August 30 – Marco Antonio Leal García, the Mayor of Hidalgo, Tamaulipas, in northeastern Mexico, is shot dead while operating his car.^[35]
• August 31 – Eight people are killed in a petrol bomb attack at a bar in Cancún, Mexico.^[36]
• September 2 – At least 17 migrants are kidnapped by suspected human traffickers in Tijuana, Baja California, in northwestern Mexico.^[37]
• September 10 – At least 71 prisoners escape from jail in the Mexican city of Reynosa, Tamaulipas, across the U.S. border from McAllen, Texas.^[38]
• September 16 – Mexico celebrates 200 years of independence from Spain.^[39]
• September 28 – 2010 Oaxaca landslide, six killed
• September 29 – Another landslide in the Mexican state of Chipas kills 16 people and leaves four missing.^[40]
• October 3 – Twenty-two Mexican tourists are kidnapped in Acapulco.^[41]
• October 7 – Six gangsters died and one soldier was injured when an army patrol clashed with suspected gang members in northeastern Mexico state Tamaulipas.^[42]
• October 18 – At least nineteen people die near Santiago de Querétaro, Mexico, after a bus collides with a truck.^[43]
• October 23 – Mexican gunmen kill 13 people and wound fifteen at a birthday party in the Mexican border city of Ciudad Juárez.^[44]
• October 24 – Mexican gunmen burst into a drug rehabilitation centre in eastern Tijuana, killing 13 people.^[45]