The 2020–21 Slovak Cup was the 52nd edition of the competition. The tournament began on 25 July 2020 and the final was played on 19 May 2021.

Slovan Bratislava were the defending champions, defeating Ružomberok in the 2020 final.

Slovan won a second consecutive title, defeating Žilina in the final.

The winner of the Slovak Cup earned automatic qualification for the second qualifying round in UEFA Europa Conference League. As Slovan had already qualified for the 2021–22 UEFA Champions League as league champion, the spot was decided by the Europa Conference League play-offs,^[1] which was eventually won by Žilina.

The Cup was played as a knockout tournament contested by 229 teams - one more than the previous edition. Teams (excluding 'B' teams) from the top five levels played along with two winners of regional cups.^[2] All ties are decided on the day with penalty shoot-outs used to decide drawn matches. All rounds are played as one-off matches except the semi-finals which are played over two legs.

In this season, the fixed amount of prize money paid to the clubs is as follows:

• Winning the final: €50,000
• Losing finalist: €20,000
• Semi-finals: €5,000

The most successful club from the regional football associations will receive a financial reward of €3,000 if they end before semifinal. Teams that participate in the 1st and 2nd round will receive match balls (for home club five and for away club three).^[3]

101 matches in the first round were played from July 25, 2020, to August 5, 2020.^[4] The first round is regional, which means that, only teams from one region meet each other. Matches of the first round drew the divisional football associations.^[5] If the score is still level after ninety minutes, a team advancing to next round will be reached by penalty shoutout.

64 matches in the second round were played from August 12, 2020, to September 16, 2020.

32 matches of the 3rd round were played from September 16. 31 matches finished until October 7. Only one match including DAC Dunajská Streda was rescheduled on a spring 2021 due COVID-19 pandemic and participation in Europa League.^[6]

Due COVID-19 pandemic all matches of the 4th and 5th rounds have been rescheduled on a spring 2021.^[7] In Slovakia from 11 October no sports event were allowed, expect top leagues of some sports.^[8]
On March 10, the organizers Slovak Football Association decided that the competition would be played only with clubs from the first and second leagues. Clubs from the lower leagues have been banned from official matches and trainings since October 2020. There were still 19 clubs from the first and second leagues left in the competition, and there were to be 16 clubs in the 5th round. 6 teams, selected by worst places from 2019–20 Slovak Cup, played an additional play-off in the 4th round. It was Dubnica, Šamorín, Podbrezová, Zemplín Michalovce, Komárno and FC Košice.^[9]

¹ Played on neutral pitch in Poprad.

^{2 3}Played on neutral pitch in Topoľčany.

The draw was on March 25. Matches were played on April 6–7.

^{1 6 8}Played on neutral pitch on NTC Senec.

^{2 4}Played on neutral pitch in Zvolen.

^{3 5 7}Played on neutral pitch in Topoľčany.

The draw was on April 8. Matches was played on April 13–14.^[10]

Košice v Trenčín

13 April 2021	Košice	3–0	Trenčín	Košice
13:30 CEST (UTC+02:00)	Gáll 18' Pačinda 70' Liener 81'	Report		Stadium: Štadión Lokomotívy Referee: Erik Gemzický

Zlaté Moravce v Žilina

13 April 2021	Zlaté Moravce	0–2	Žilina	Zlaté Moravce
15:30 CEST (UTC+02:00)		Report	Rusnák 33' Paur 87'	Stadium: Štadión FC ViOn Referee: Michal Smolák

Dukla Banská Bystrica v DAC Dunajská Streda

14 April 2021	Dukla Banská Bystrica	3–2	DAC Dunajská Streda	Zvolen
13:30 CEST (UTC+02:00)	Kupčík 2' Frimmel 69' Tóth 90+3'	Report	Müller 20' Beskorovainyi 66'	Stadium: Štadión MFK Zvolen Referee: Martin Dohál

Slovan Bratislava v Petržalka

14 April 2021	Slovan Bratislava	5–1	Petržalka	Bratislava
15:30 CEST (UTC+02:00)	Abena 13' De Marco 19' Strelec 40' Daniel 46' Holman 67'	Report	De Marco 79' (o.g.)	Stadium: Tehelné pole Referee: Marián Ruc

The draw was on April 15. Semi-finals was played on April 28 and May 5.

First leg

Košice v Žilina

28 April 2021	Košice	2–4	Žilina	Košice
15:30 CEST (UTC+02:00)	Pačinda 47', 86'	Report	Slebodník 28' Kaprálik 41', 65' Bernát 87'	Stadium: Štadión Lokomotívy Referee: Adam Somoláni

Slovan Bratislava v Dukla Banská Bystrica

29 April 2021	Slovan Bratislava	3–0	Dukla Banská Bystrica	Bratislava
15:30 CEST (UTC+02:00)	De Marco 31' Strelec 64' Ožbolt 81'	Report		Stadium: Tehelné pole Referee: Peter Ziemba

Second leg

Žilina v Košice

4 May 2021	Žilina	4–1 (8–3 agg.)	Košice	Žilina
15:30 CEST (UTC+02:00)	Ďuriš 1' Bichakhchyan 12' (pen.) Myslovič 38' Minárik 90'	Report	Pačinda 17'	Stadium: Štadión pod Dubňom Referee: Martin Dohál

Dukla Banská Bystrica v Slovan Bratislava

5 May 2021	Dukla Banská Bystrica	1–3 (1–6 agg.)	Slovan Bratislava	Zvolen
15:30 CEST (UTC+02:00)	Abena 20' (o.g.)	Report	Henty 9' Ožbolt 25' Lovat 89'	Stadium: Štadión MFK Zvolen Referee: Bálint Kišš

• 2020–21 Slovak First Football League