April

April 1–April 4, vs. Baltimore Orioles

Rain caused Boston's first game to be postponed from April 1 to April 2. Nathan Eovaldi started the opener, as he had done the prior season, lasting 5+1⁄3 innings while allowing one run on four hits and striking out four batters. The Red Sox were limited to two hits and two walks, taking a 3–0 loss. Baltimore also took the second game of the series, 4–2. Red Sox starter Tanner Houck held the Orioles to two runs on six hits in five innings, while striking out eight. The Orioles completed the sweep with an 11–3 win in the third game of the series. Garrett Richards took the loss in his first start for Boston, allowing six runs on seven hits in two innings. J. D. Martinez hit the Red Sox' first home run of the season. The most recent time the Red Sox had started a season 0–3 at Fenway Park was 1948,^[74] opening that season with losses to the Philadelphia Athletics.^[75]

Red Sox lost the series 0–3 (5–18 runs)

April 5–April 7, vs. Tampa Bay Rays

The Red Sox' first win of the season came in the series opener against Tampa Bay, 11–2. Starter Nick Pivetta pitched five scoreless innings and got the win. J. D. Martinez hit his second home run of the season, while Xander Bogaerts had four hits and an RBI. The Red Sox tied the second game of the series at 3–3 in the bottom of the ninth inning via a Christian Vázquez home run, sending the game into extra innings. After a scoreless 10th inning, the teams traded runs in the 11th inning, making the score 4–4. After Tampa Bay took a 5–4 lead in the top of the 12th inning, Martinez hit a two-out double in the bottom of the 12th with runners at second and third, driving in both runs and giving Boston a 6–5 victory. Red Sox reliever Phillips Valdéz got the win. Boston completed the sweep with a 9–2 win in the third game of the series, as starter Nathan Eovaldi went seven innings while striking out seven and holding the Rays to three hits and one run. Vázquez hit his second home run of the season and Bogaerts went 3-for-3.

Red Sox won the series 3–0 (26–9 runs)

April 8–April 11, at Baltimore Orioles

The Red Sox' first road game of the year was a 7–3 win at Baltimore in the Orioles' home opener. Starter Eduardo Rodríguez, who had missed the 2020 season due to myocarditis, got the win. Rafael Devers and Kiké Hernández both homered. The second game of the series went into extra innings after the Red Sox tied the game, 4–4, in the top of the ninth. After Boston scored two runs in the top of the 10th, Matt Andriese held the Orioles scoreless in the bottom of the inning, securing his first save of the season and the Red Sox' fifth consecutive win. Devers again homered. Boston completed the sweep with a 14–9 win in the final game of the series, after building a 9–1 lead through five innings. Starter Nick Pivetta earned his second win of the season, while the offense had six home runs—three by J. D. Martinez, two by Devers, and one by Alex Verdugo.

Red Sox won the series 3–0 (27–16 runs)

April 12–April 15, at Minnesota Twins

The opener of a four-game series in Minneapolis was postponed shortly before its scheduled start time, for "the safety of all of those involved" following the killing of Daunte Wright the day before in nearby Brooklyn Center, Minnesota.^[76] The postponed game was rescheduled as part of a single-admission doubleheader on April 14, with both games seven-inning contests per 2021 MLB rules for doubleheaders.^[77] The Red Sox won the first game played in the series, 4–2, with reliever Adam Ottavino collecting the win and Matt Barnes earning his first save of the season. Hunter Renfroe and Rafael Devers both homered, as Boston extended their winning streak to seven games. For the doubleheader, Boston activated pitcher Eduard Bazardo as their extra player.^[78] The first game of the doubleheader was a 3–2 Red Sox victory, with starter Nathan Eovaldi getting the win; Barnes recorded the save. The Red Sox extended their winning streak to nine games via a 7–1 win in the second game of the doubleheader. Eduardo Rodríguez started and got the win; Bazardo pitched a scoreless inning of relief in his MLB debut. Alex Verdugo was 3-for-4 at the plate with a home run and three RBIs. The winning streak ended with a 4–3 loss to the Twins in the final game of the series, with the deciding run coming in the bottom of the ninth inning off of reliever Ottavino, who took the loss. The Red Sox were limited to four hits; Verdugo drove in all three Boston runs.

Red Sox won the series 3–1 (17–9 runs)

April 16–April 19, vs. Chicago White Sox

The opening game hosting the White Sox was postponed due to inclement weather, and was rescheduled to be played as part of a separate-admission doubleheader two days later.^[79] The Red Sox won the first game played, 7–4, breaking a 3–3 tie with a four-run eighth inning. Reliever Adam Ottavino got the win, Marwin González homered, and both Kiké Hernández and Xander Bogaerts went 4-for-5 at the plate. Chicago won the first game of the doubleheader, 3–2 in seven innings, as starter Tanner Houck took the loss. Hernández homered. The second game of the doubleheader was also won by the White Sox, 5–1 in seven innings, with the loss going to starter Martín Pérez. Boston won the final game of the series, 11–4, behind an early offensive outburst. Hernández, J. D. Martinez, and Alex Verdugo all hit home runs while White Sox starter Lucas Giolito was chased from the game in the second inning without recording an out. All Red Sox starters reached base, with Bobby Dalbec the only one that did not record a hit.

Red Sox split the series 2–2 (21–16 runs)

April 20–April 21, vs. Toronto Blue Jays

The Red Sox won the first game, 4–2, over the Blue Jays behind a home run from Xander Bogaerts and strong starting pitching from Eduardo Rodríguez, who earned the win. Matt Barnes earned a three-out save. Toronto won the second and final game of the series, 6–3, as Boston starter Garrett Richards took the loss. Bogaerts again homered.

Red Sox split the series 1–1 (7–8 runs)

April 22–April 25, vs. Seattle Mariners

In the first game of a four-game series, Red Sox starter Nick Pivetta allowed only a single hit in six innings of work, although the one hit—by Seattle DH Ty France—drove in two baserunners who had walked. The game was tied 2–2 after six innings, and 3–3 after nine innings. In the 10th inning, the Mariners scored four runs (three earned) off of two hits and two walks allowed by reliever Darwinzon Hernández, who took the loss after Boston was unable to score in the bottom of the inning. Rafael Devers homered. In game two, the Red Sox bounced back for a 6–5 win behind a three-hit effort from Alex Verdugo. J. D. Martinez and Xander Bogaerts both contributed home runs. Seattle mounted a rally in the ninth inning capped by a Kyle Seager three-run homer, but Matt Barnes was able to hold the lead. Reliever Hirokazu Sawamura got his first MLB win. Seattle took the third game of the series, 8–2, handing Boston starter Nathan Eovaldi the loss after scoring five runs (four earned) on seven hits in the first five innings. The Red Sox won the final game of the series, 5–3, with four of the runs coming in the first inning off of Mariners starter Nick Margevicius, who lasted only 1⁄3 of an inning. Eduardo Rodríguez and Matt Barnes earned their fourth win and fourth save of the season, respectively.

Red Sox split the series 2–2 (16–23 runs)

April 27–April 28, at New York Mets

Boston took the first game of a two-game series, 2–1, behind the starting pitching of Garrett Richards. Richards posted 10 strikeouts while walking none in a strong seven-inning effort. The Red Sox scored on Bobby Dalbec's first home run of the season and a Rafael Devers RBI single. Boston won the second game, 1–0, with Christian Vázquez driving in the only run, in the second inning. Red Sox starter Nick Pivetta allowed only one hit in five innings of work, earning the win. Matt Barnes notched his sixth save of the season.

Red Sox won the series 2–0 (3–1 runs)

April 29–April 30, at Texas Rangers

Texas won the opener of a four-game series, 4–1. Boston was held to three total hits, with their only run driven in by Rafael Devers; starter Martín Pérez took the loss. Boston won the second game of the series, 6–1, led by two home runs by J. D. Martinez and one each by Xander Bogaerts and Devers. Starter Nathan Eovaldi held the Rangers to one run on four hits in six innings to earn the win. The Red Sox ended April with a record of 17–10, good for first place in the American League East, 3+1⁄2 games ahead of the second-place Toronto Blue Jays.

May

The Red Sox entered May atop the American League East with a record of 17–10, having just split the first two games of a four-game series against the Rangers.

May 1–May 2, at Texas Rangers (cont'd)

Texas won the third game of the series, 8–6, outscoring Boston by a 4–1 margin after the fifth inning. Starter Eduardo Rodríguez had a no decision with reliever Matt Andriese taking the loss after allowing three runs on three hits in the sixth inning. Hunter Renfroe homered. The Rangers also won the final game of the series, 5–3, scoring three runs (two earned) in the bottom of the eighth inning off of Red Sox reliever Adam Ottavino, who took the loss. Xander Bogaerts was 3-for-4 at the plate including a home run.

Red Sox lost the series 1–3 (16–18 runs)

May 4–May 6, vs. Detroit Tigers

In the opening game of a three-game series, Boston built an 8–2 lead after three innings, and went on to win, 11–7, in a game with 24 total hits and four errors. Starter Nick Pivetta got the win, and closer Matt Barnes earned the save. Alex Verdugo, Xander Bogaerts, Hunter Renfroe, and Kiké Hernández each homered. Boston lost the second game of the series in extra innings, 6–5. Trailing by a 3–1 score, the Red Sox tied the game, 3–3, in the seventh inning. With that same score in the top of the 10th inning, the Tigers scored three runs (two earned) off of reliever Garrett Whitlock, who took the loss. Boston's rally in the bottom of the 10th inning came up a run short. J. D. Martinez hit his 10th home run of the season. The final game of the series, which featured 30 total hits and six errors, was won by Boston, 12–9. After taking an early 4–1 lead, the Red Sox were at a 9–8 deficit entering the bottom of the eighth inning, before pushing across their final four runs. Reliever Matt Andriese got the win, and Adam Ottavino notched his first save for Boston.

Red Sox won the series 2–1 (28–22 runs)

May 7–May 10, at Baltimore Orioles

After rain delayed the start of the first game of the series by 98 minutes, Boston won, 6–2, with starter Eduardo Rodríguez improving to 5–0 for the season. Bobby Dalbec homered. The Red Sox won the second game of the series, 11–6, with starter Garrett Richards getting the win. Michael Chavis (called up after Kiké Hernández went on the injured list) and Xander Bogaerts each homered. Starter Nick Pivetta went to 5–0 on the season via Boston's 4–3 win in the third game of the series. Matt Barnes earned the save; Rafael Devers and Hunter Renfroe homered. Baltimore avoided the sweep by winning the final game, 4–1. Devers drove in the only Boston run, via a sacrifice fly. Reliever Matt Andriese took the loss, allowing three runs on four hits in two innings.

Red Sox won the series 3–1 (22–15 runs)

May 11–May 13, vs. Oakland Athletics

Oakland won the opening game of a three-game series, 3–2. Boston starter Nathan Eovaldi held the A's to one run on two hits in six innings, with the loss going to reliever Darwinzon Hernández who allowed two runs on two hits and a walk in only 1⁄3 of an inning. Rafael Devers hit his ninth home run of the season. The second game of the series was also an Oakland win, 4–1. Boston's only run came on a bases-loaded walk in the first inning; the team was held to five hits and left a total of eight men on base. Starter Eduardo Rodríguez took the loss. The Red Sox avoided being swept with an 8–1 win in the final game of the series. Starter Garrett Richards earned the win, with reliever Garrett Whitlock earning a three-inning save. Xander Bogaerts and Bobby Dalbec homered.

Red Sox lost the series 1–2 (11–8 runs)

May 14–May 16, vs. Los Angeles Angels

The Red Sox won the series opener against the Angels, 4–3. Starter Nick Pivetta held Los Angeles to two runs on four hits in six innings, but received a no decision as the win went to reliever Matt Andriese. Closer Matt Barnes earned his ninth save of the season. Hunter Renfroe and Bobby Dalbec homered. In the second game of the series, Boston built a 4–0 lead through four innings, en route to a 9–0 win. Starter Martín Pérez earned his first win of the season. Alex Verdugo, Xander Bogaerts, and Rafael Devers each homered. The Angels won the final game of the series, 6–5, taking a late lead with two runs in the top of the ninth inning off of Barnes, who took the loss. Boston backup catcher Kevin Plawecki hit his first home run of the season.

Red Sox won the series 2–1 (18–9 runs)

May 18–May 20, at Toronto Blue Jays (in Florida)

Due to travel restrictions related to the COVID-19 pandemic, the Blue Jays began the 2021 season playing home games at their spring training facility—TD Ballpark in Dunedin, Florida. The Blue Jays won the opening game of the series, 8–0, scoring five runs in five innings off of Boston starter Eduardo Rodríguez, who took the loss. The second game was won by the Red Sox, 7–3. Starter Garrett Richards held the Blue Jays to two runs on seven hits in 6+2⁄3 innings and earned the win. Alex Verdugo, J. D. Martinez, Kiké Hernández, and Christian Vázquez each homered. The Red Sox won the final game of the series, 8–7, with three runs in the top of the ninth inning to turn a two-run deficit into a one-run lead. Martinez and Bobby Dalbec homered, while Matt Barnes recorded his 10th save of the season.

Red Sox won the series 2–1 (15–18 runs)

May 21–May 23, at Philadelphia Phillies

The Red Sox won the first game of a three-game road series in Philadelphia, 11–3, with starter Martín Pérez getting the win. In his debut game with Boston, utility player Danny Santana homered, while Rafael Devers hit his 12th of the season. The second game was also won by Boston, 4–3, with starter Nathan Eovaldi earning his fifth win of the season and closer Matt Barnes notching his 11th save. Santana again homered, as did Xander Bogaerts. The Phillies won the final game of the series, 6–2, giving Red Sox starter Eduardo Rodríguez his third loss of the season. Devers and Franchy Cordero each homered.

Red Sox won the series 2–1 (17–12 runs)

May 25–May 26, vs. Atlanta Braves

Entering a two-game home series with Atlanta, the Red Sox (29–19) were no longer atop the AL East for the first time since early in the season, one-half game behind Tampa Bay (30–19). The Braves won the first game, 3–1, with Boston starter Garrett Richards taking the loss. The Red Sox' only run came in the bottom of the first inning, when Rafael Devers was hit by a pitch with the bases loaded. The second game, including a two-hour and 53-minute rain delay, was won by Boston, 9–5. Starter Nick Pivetta improved his season record to 6–0. Devers and Hunter Renfroe both homered.

Red Sox split the series 1–1 (10–8 runs)

May 28–May 30, vs. Miami Marlins

The Red Sox opened a three-game home series against the Marlins with a 5–2 win, in a game ended by rain in the sixth inning. The winning runs were driven in by Alex Verdugo via a three-run homer in the fifth inning. Starter Martín Pérez earned the win. Boston also won the second game of the series, 3–1, which was delayed by rain for 16 minutes but lasted its scheduled nine innings. Attendance at Fenway Park was 25,089 in the first game played following the State of Massachusetts lifting COVID-19 restrictions on sports events.^[7] Starter Nathan Eovaldi improved to 6–2 on the season with closer Matt Barnes allowing one run before securing his 12th save. Rafael Devers and Hunter Renfroe each went 3-for-4 at the plate. The final game of the series was postponed due to rain, with an announced makeup date of June 7.^[80]

Red Sox won the series 2–0 (8–3 runs)

May 31, at Houston Astros

This series marked the first time that Alex Cora visited Houston since the Houston Astros sign stealing scandal became public, which led to Cora being suspended for the 2020 season, due to his role in the scandal while he was Houston's bench coach in 2017.^[81] In the first game of a four-game series, the Astros jumped out to an early 4–0 lead after three innings, en route to an 11–2 win. Starter Eduardo Rodríguez took the loss. Hunter Renfroe was the only Boston player with more than one hit, one of them a home run. The Red Sox ended May with a record of 32–21, two games behind the Tampa Bay Rays in the American League East.

June

The Red Sox entered June in second place in the American League East with a record of 32–21, having just lost the first game of a four-game series against the Astros.

June 1–June 3, at Houston Astros (cont'd)

Houston won the second game of the series, 5–1, handing Boston starter Garrett Richards his fourth loss of the season. Alex Verdugo had two of the Red Sox' five hits. Houston also won the third game of the series, 2–1, as Boston starter Nick Pivetta suffered his first loss of the season. Hunter Renfroe drove in the only Red Sox run. Boston avoided being swept with a 5–1 win in the final game of the series; starter Martín Pérez earned the win. Christian Arroyo hit a three-run home run.

Red Sox lost the series 1–3 (9–19 runs)

June 4–June 6, at New York Yankees

In the first series of the season against the Yankees, the Red Sox jumped out to an early lead via a Rafael Devers three-run home run in the top of the first inning. Nathan Eovaldi held New York to two runs (one earned) on eight hits in six innings to earn the win; Matt Barnes closed out the 5–2 win with his 13th save of the season. Boston came back from a 2–0 deficit to win the second game of the series, 7–3. Bobby Dalbec had a two-run home, and Devers also drove in two runs. Garrett Whitlock earned the win in relief, while Barnes was brought in to record the final out after the Yankees put two baserunners on in the ninth. The Red Sox completed the sweep with a 6–5 win in the third game of the series. Down 3–1 after six innings, Boston scored twice in the seventh and once in the eighth and held a 4–3 lead in the bottom of the ninth. However, Barnes was unable to convert the save as the Yankees tied the game and forced extra innings. Xander Bogaerts drove in two runs in the top of the tenth, and Phillips Valdéz held the Yankees to one run in the bottom of the inning to secure his first major league save. Alex Verdugo and Marwin González each homered. This was the first time that the Red Sox swept the Yankees in a three-game series at Yankee Stadium since June 7–9, 2011.^[9][82]

Red Sox won the series 3–0 (18–10 runs)

June 7, vs. Miami Marlins

In the makeup of a May 30 rainout, Boston won their fifth game in a row, defeating the Marlins, 5–3. Starter Nick Pivetta held the Marlins to two runs on seven hits, but left after 4+2⁄3 innings—the win was awarded to reliever Hirokazu Sawamura, the fourth of six Boston pitchers in the game. Adam Ottavino recorded the final four outs for the save.

Red Sox won the series 1–0 (5–3 runs)

June 8–June 10, vs. Houston Astros

In the opener of a three-game series, Houston jumped out to an early 6–0 lead and went on to win, 7–1. Starter Martín Pérez only lasted two innings and took the loss. Hunter Renfroe drove in Boston's only run. The Astros also won the second game of the series, 8–3. Starter Nathan Eovaldi took the loss after allowing five runs on 11 hits in 5+2⁄3 innings. Xander Bogaerts drove in two of Boston's runs via a fourth-inning homer. The third game of the series featured 24 hits, 20 runs, and the ejection of Houston manager Dusty Baker, as the Red Sox avoided being swept via a 12–8 win. J. D. Martinez and Christian Arroyo both homered, and Christian Vázquez went 3-for-4 with three RBIs. Darwinzon Hernández, the third of six Boston pitchers, got the win.

Red Sox lost the series 1–2 (16–23 runs)

June 11–June 14, vs. Toronto Blue Jays

Boston was outhit by Toronto, 16–8, in the opener of a four-game series, but came away with a 6–5 win. The Blue Jays held a lead from the top of the first inning until the bottom of the eighth, when the Red Sox tied the score at 5–5. A Toronto error in the bottom of the ninth put a runner on second base, and Alex Verdugo, who went 3-for-4, then drove in the winning run with a single off of the Green Monster. Bobby Dalbec and Christian Arroyo each homered; reliever Garrett Whitlock got the win. Toronto jumped out to an early 2–0 lead in the second game of the series and went on to win, 7–2. Starter Nick Pivetta took the loss. The third game of the series was an 18–4 win by the Blue Jays, who had eight home runs and 20 hits. The eight home runs set a new single-game record for a visiting team at Fenway Park.^[10] Starter Martín Pérez fell to 4–4 on the season after allowing five runs in 1+1⁄3 innings. He was followed by Ryan Weber, who allowed 11 runs in 5+2⁄3 innings. Position players Arroyo and Marwin González each pitched an inning. Offensively, Dalbec and Xander Bogaerts each homered. Boston won the final game of the series, 2–1. After the Red Sox held a 1–0 lead from the third inning, Boston closer Matt Barnes allowed a game-tying home run to Vladimir Guerrero Jr. in the top of the ninth inning. In the bottom of the ninth, Rafael Devers drove in the winning run via a one-out double with two men on base. Starter Nathan Eovaldi held the Blue Jays to three hits and no runs in 6+2⁄3 innings but received a no decision.

Red Sox split the series 2–2 (14–31 runs)

June 15–June 16, at Atlanta Braves

Boston won the opening game of a two-game series, 10–8, after building an early 5–0 lead. Rafael Devers, Hunter Renfroe, Xander Bogaerts, and Alex Verdugo each homered. Starter Eduardo Rodríguez left after four innings, having allowed four runs on six hits; reliever Hirokazu Sawamura, the fourth of six Boston pitchers, got the win. Matt Barnes recorded his 15th save of the season. The second game of the series was also a Red Sox win by the same score, 10–8. Christian Arroyo hit Boston's first grand slam of the season, coming the seventh inning and turning a 6–7 deficit into a 10–7 lead. Reliever Yacksel Ríos made his Red Sox debut and earned the win; he was the third of seven Boston pitchers in the game. Starter Garrett Richards allowed six runs on seven hits in four innings; Adam Ottavino earned the save.

Red Sox won the series 2–0 (20–16 runs)

June 18–June 20, at Kansas City Royals

Kansas City won the first game of a three-game series, 5–3, dropping Boston starter Nick Pivetta to 6–3 on the season. Rafael Devers hit his 17th home run of the season. Christian Arroyo became the first Red Sox player to be ejected during the 2021 season, via a ninth-inning strike-zone disagreement with home plate umpire Jim Wolf. The Red Sox were 7–1 winners in the second game of the series, with starter Martín Pérez getting the win. Bobby Dalbec was 3-for-3 including a home run; J. D. Martinez also homered. The win put Boston into a tie with Tampa Bay atop the AL East at 43–28; the Rays later lost to the Mariners, giving the Red Sox sole possession of the divisional lead for the first time since May 22.^[83] The third game of the series was won by the Royals, 7–3. Starter Nathan Eovaldi allowed seven hits and four runs in four innings and took the loss. Catcher Kevin Plawecki and second baseman Arroyo both left the game with injuries.^[84] Devers and Kiké Hernández each homered.

Red Sox lost the series 1–2 (13–13 runs)

June 22–June 24, at Tampa Bay Rays

Boston won the opener of a three-game series, 9–5 in 11 innings. Boston starter Eduardo Rodríguez received a no decision after allowing five runs (three earned) on seven hits in six innings. After the game remained tied, 5–5, for the 6th through 10th innings, Boston scored four unanswered runs in the top of the 11th inning.^{[lower-alpha 2]} Xander Bogaerts was 3-for-5, while Hunter Renfroe had a home run and three RBIs. Reliever Darwinzon Hernández recorded the final four outs and got the win. Tampa Bay won the second game of the series, 8–2, as Boston starter Garrett Richards only lasted 1+2⁄3 innings while allowing five runs (four earned) on three hits and four walks. Both teams had six hits, with the Red Sox drawing six walks and the Rays drawing nine. The Rays won the final game of the series, 1–0. Red Sox starter Nick Pivetta left the game after 6+2⁄3 innings having thrown 100 pitches and not allowing a hit. The Rays collected their first hit with one out in the eighth inning, off of reliever Darwinzon Hernández. With two outs in the ninth inning, Rays designated hitter Manuel Margot singled, stole second and advanced to third on a throwing error by catcher Christian Vázquez. Margot then scored the only run of the game via a wild pitch from closer Matt Barnes, who took the loss. The win put Tampa Bay back into first place atop the AL East at 45–31, one-half game ahead of Boston at 44–31.

Red Sox lost the series 1–2 (11–14 runs)

June 25–June 27, vs. New York Yankees

The Red Sox honored Dustin Pedroia, who retired in February, in a ceremony prior to the first game of the series.^[86] Boston won the series opener, 5–3. After reaching a 3–3 tie in the middle of the second inning, Boston scored the game's only other runs; one each in the third and eighth innings. Starter Martín Pérez received a no decision after allowing three runs on six hits in 3+2⁄3 innings. The win went to Garrett Whitlock, the third of five Boston pitchers; closer Matt Barnes got the save. Xander Bogaerts and Hunter Renfroe each had two RBIs. Boston also won the second game of the series, 4–2. Starter Nathan Eovaldi held the Yankees to a single run on seven hits in 7+2⁄3 innings and earned the win; Adam Ottavino earned his fifth save of the season in recording the final four outs. Bogaerts and Renfroe each had three hits and an RBI. Catcher Connor Wong collected his first MLB hit. The Red Sox completed the series sweep with a 9–2 win in the third game. Starter Eduardo Rodríguez earned the win, holding the Yankees to two runs on five hits in six innings. Boston had four home runs, one each by Kiké Hernández, Rafael Devers, J. D. Martinez, and Christian Vázquez. The win put Boston back atop the AL East at 47–31, a one-half game ahead of Tampa Bay at 47–32.

Red Sox won the series 3–0 (18–7 runs)

June 28–June 30, vs. Kansas City Royals

The Red Sox opened a four-game series against the Royals with a 6–5 win, recovering from a 5–2 deficit after the first two innings. Hunter Renfroe hit two home runs, while Kiké Hernández and Bobby Dalbec each hit one. Starter Garrett Richards received a no decision after allowing five runs on 11 hits in 5+2⁄3 innings. The win went to reliever Hirokazu Sawamura, the second of four Boston pitchers in the game. Closer Matt Barnes recorded his 17th save of the season. Boston won the second game of the series, 7–6, extending their winning streak to five games. J. D. Martinez was 2-for-2 with two walks and four RBIs. Starter Nick Pivetta left after 4+1⁄3 innings; reliever Yacksel Ríos recorded the next five outs and earned the win, while Barnes earned another save. The Red Sox extended their winning streak to six games, via a 6–2 win in the third game of the series. Rain delayed the start of the game, and halted play, for a total of two hours and 21 minutes. Starter Martín Pérez earned the win. Martinez and Renfroe each homered. The Red Sox ended June with a record of 50–31, leading the American League East by three games over the Tampa Bay Rays.

July

The Red Sox entered July atop the American League East with a record of 50–31, having just won the first three games of a four-game series against the Royals.

July 1, vs. Kansas City Royals (cont'd)

The Red Sox' winning streak reached seven games as the team completed a four-game sweep of the Royals with a 15–1 win. Starter Nathan Eovaldi held Kansas City scoreless through seven innings, followed by reliever Matt Andriese who pitched the final two innings and allowed only an unearned run. Each Boston starter had at least one hit. Kiké Hernández, J. D. Martinez, Danny Santana, and Rafael Devers each homered.

Red Sox won the series 4–0 (34–14 runs)

July 2–July 4, at Oakland Athletics

The opener of a three-game road series in Oakland was a 3–2 extra innings win for Boston, extending the winning streak to eight games. Kiké Hernández drove in the winning run in the top of the 10th, with Adam Ottavino holding the Athletics scoreless in the bottom of the inning for the save. Closer Matt Barnes, who blew a save in the bottom of the ninth, was credited with the win. Starter Eduardo Rodríguez allowed no runs and only a single hit in six innings, but had to settle for a no decision. The second game of the series also went to extra innings, tied 4–4. After Boston starter Garrett Richards held Oakland to two runs on five hits in five innings, the Athletics tied the game in the eighth inning via two runs off of reliever Yacksel Ríos. J. D. Martinez, playing left field, threw out Athletics catcher Sean Murphy at the plate in the bottom of the 10th inning, preserving the tie. After a scoreless 11th inning, the Red Sox scored twice in the top of the 12th to take a 6–4 lead. However, Oakland scored three runs off of Matt Andriese in the bottom of the inning for a 7–6 win. Hernández hit his 10th home run of the season. The final game of the series was a 1–0 Boston win, with the only run of the game coming on a double–single–ground-out sequence in the sixth inning. Alex Verdugo scored the run, and was the only player in the game with more than one hit. Starter Nick Pivetta allowed just two hits in seven innings for the win, while Barnes earned his 19th save of the season.

Red Sox won the series 2–1 (10–9 runs)

July 5–July 7, at Los Angeles Angels

The first game of a three-game series with the Angels was won by the Red Sox, 5–4. Starter Martín Pérez got the win, having held Los Angeles to one run on eight hits in 5+1⁄3 innings. Adam Ottavino notched his seventh save of the season. Rafael Devers had three hits, include a home run; Christian Arroyo also homered. The Angels won the second game of the series, 5–3, with all their runs scored off of starter Nathan Eovaldi, who lasted 5+2⁄3 innings and took the loss. Hunter Renfroe homered. The final game of the series was a 5–4 Angels win, dropping starter Eduardo Rodríguez to a 6–5 record for the season. Xander Bogaerts went 3-for-4 at the plate.

Red Sox lost the series 1–2 (12–14 runs)

July 9–July 11, vs. Philadelphia Phillies

Boston won the opener of a three-game home series against the Phillies, 11–5. Starter Garrett Richards got the win, improving to 5–5 on the season. Six different Red Sox batters had two hits apiece, while J. D. Martinez, Kiké Hernández, and Rafael Devers each homered. The Phillies won the second game of the series, 11–2. Holding a 3–2 lead after seven innings, Philadelphia scored eight runs in the top of the eighth inning to put the game out of reach. Starter Martín Pérez allowed three runs on six hits, exiting after 3+2⁄3 innings and taking the loss. Xander Bogaerts hit his 14th home run of the season. The final game of the series was another Phillies win, 5–4. Starter Nick Pivetta took the loss against his former team, allowing five runs on four hits in four innings. Bogaerts homered again. The Red Sox reached the All-Star break atop the American League East with a record of 55–36, 1+1⁄2 games ahead of Tampa Bay.

Red Sox lost the series 1–2 (17–21 runs)

The Red Sox had five players selected to the All-Star Game; all five played as the American League defeated the National League, 5–2.^[87] Xander Bogaerts and Rafael Devers started the game at shortstop and third base, respectively. Bogaerts went 2-for-3 at the plate with an RBI, while Devers went 1-for-2. They were replaced by reserve players in the bottom of the fifth inning. Nathan Eovaldi pitched the fourth inning, allowing no runs on one hit. J. D. Martinez entered the game as designated hitter in the top of the fifth inning and went 0-for-2. Matt Barnes pitched the eighth inning, allowing no runs on two hits and a walk.

July 15–July 18, at New York Yankees

The opener of a four-game series at Yankee Stadium was postponed due to three positive COVID-19 test results within the Yankees' pitching staff.^[88] The next day, Boston won the first game played in the series, 4–0. Starter Eduardo Rodríguez allowed only two hits in 5+2⁄3 innings and earned the win. Tanner Houck pitched the final three innings, earning a save. Christian Arroyo and J. D. Martinez each homered. The Yankees won the second game of the series, 3–1, in a six-inning rain-shortened contest. Starter Nathan Eovaldi held the Yankees to one run on two hits in five innings, leaving with a no decision. Reliever Hirokazu Sawamura allowed two home runs in the bottom of the sixth, and took the loss. The game included the MLB debut of Jarren Duran, the ejections of bench coach Will Venable and backup catcher Kevin Plawecki following a check-swing third-strike call that the Red Sox dugout took exception to, and a brief stoppage in play after left fielder Alex Verdugo was struck in the back by a baseball thrown by a fan.^[89] The final game of the series was a 9–1 New York win, as starter Martín Pérez allowed three runs on five hits in four innings, taking the loss. Xander Bogaerts was the only Red Sox batter with two hits, while Hunter Renfroe had the only RBI.

Red Sox lost the series 1–2 (6–12 runs)

July 19–July 21, at Toronto Blue Jays (in Buffalo)

Boston won the first game of a three-game series played in Buffalo, New York, 13–4. J. D. Martinez was 4-for-4 with a walk, while Kiké Hernández hit two home runs. Boston also had home runs from Jarren Duran, Hunter Renfroe (a grand slam), Rafael Devers, and Danny Santana. Starter Nick Pivetta allowed four runs on 11 hits in 6+2⁄3 innings and earned the win. The second game of the series was rained out, with a makeup game scheduled for August 7.^[90] Boston won the final game of the series, 7–4. Starter Garrett Richards earned the win, allowing four runs on four hits in 5+2⁄3 innings, and Matt Barnes earned his 20th save of the season. Hernández, Devers, Martinez, Renfroe, and Michael Chavis each homered.

Red Sox won the series 2–0 (20–8 runs)

July 22–July 25, vs. New York Yankees

The first game of a four-game home series against the Yankees was a 5–4 extra-innings win. Starter Tanner Houck left after 4+2⁄3 innings due to a 55 minute rain delay, having held New York to one unearned run on two hits. Trailing 3–1 entering the bottom of the ninth, Kiké Hernández drove in two runs via a two-out double to tie the game. The Yankees scored one run off of Matt Barnes in the top of the 10th. In the bottom of the inning, Boston scored twice, taking advantage of four wild pitches by Yankees reliever Brooks Kriske; Hunter Renfroe drove in the winning run via a sacrifice fly. The second game of the series was a 6–2 Boston win. Trailing 1–0 entering the bottom of the fifth, the Red Sox scored three runs, then added three more in the bottom of the seventh. Rafael Devers had five RBIs via two home runs. Starter Eduardo Rodríguez left in the second inning due to migraine symptoms.^[91] Yacksel Ríos, the third of five Boston relievers who followed Rodríguez, allowed no runs or hits in two innings of work and got the win. In the second game of the series, Boston took an early 3–0 lead, but the Yankees scored four unanswered runs in the eighth inning to give the Red Sox a 4–3 defeat. Starter Nathan Eovaldi lasted 7+2⁄3 innings and allowed two runs on seven hits; reliever Adam Ottavino allowed two runs on three hits in 1⁄3 of an inning and took the loss. Kevin Plawecki was the only Boston batter with two hits. The final game of the series was a 5–4 Red Sox win. Entering the bottom of the eighth inning, Boston had not recorded a hit and trailed, 4–0. Five consecutive hits and a sacrifice fly put the Red Sox ahead by a run. Barnes then closed out the game for his 21st save of the season. The win went to Brandon Workman, the third of four relievers who followed starter Martín Pérez.

Red Sox won the series 3–1 (19–14 runs)

July 26–July 29, vs. Toronto Blue Jays

The Red Sox won the first game of a four-game home series against Toronto, 5–4. Boston's 3–2 fifth-inning lead became a 4–3 deficit via a two-run Bo Bichette homer. Alex Verdugo's own two-run homer in the eighth inning put Boston back in the lead, allowing Matt Barnes to close out the game with his 22nd save of the year. Starter Nick Pivetta had a no decision after allowing four runs on six hits in 4+2⁄3 innings; reliever Adam Ottavino got the win. Rafael Devers also homered. The second game of the series was postponed due to rain, resulting in a doubleheader being scheduled for the following day.^[92] The first game of the doubleheader was won by the Blue Jays, 4–1, in seven innings. Starter Garrett Richards allowed four runs on eight hits in four innings and took the loss. J. D. Martinez drove in Boston's only run. The second game of the doubleheader was a Boston win, also by a 4–1 score in seven innings. Starter Tanner Houck allowed one run in four innings; the win went to reliever Garrett Whitlock, who pitched two scoreless innings, while Barnes registered another save. Kevin Plawecki had three hits, and Jarren Duran had two RBIs. The final game of the series was a 13–1 Blue Jays win, with starter Eduardo Rodríguez taking the loss after allowing six runs in 3+1⁄3 innings. Bobby Dalbec drove in Boston's only run. Red Sox backup catcher Plawecki pitched a scoreless ninth inning.

Red Sox split the series 2–2 (11–22 runs)

July 30–July 31, at Tampa Bay Rays

Tampa Bay won the opener of a three-game series, 7–3, dropping starter Martín Pérez to a 7–7 record for the season. The second game of the series was also won by the Rays, 9–5. Starter Nathan Eovaldi allowed six runs (five earned) on six hits in 5+1⁄3 innings and took the loss. Xander Bogaerts and Bobby Dalbec each homered. The Rays ended July back in the lead of the American League East with a 63–42 record, one-half game ahead of the Red Sox at 63–43.^[93]

August

The Red Sox entered August in second place in the American League East with a record of 63–43, having just lost the first two games of a three-game series against the division-leading Rays (63–42).

August 1, vs. Tampa Bay Rays (cont'd)

The Rays completed a three-game sweep with a 3–2 win. Red Sox started Nick Pivetta took the loss; he allowed three runs on three hits in 4+2⁄3 innings. Kiké Hernández had three hits and Hunter Renfroe homered. Boston had runners at first and third with two outs in the ninth, but were unable to push across the tying run.

Red Sox lost the series 0–3 (10–19 runs)

August 3–August 5, at Detroit Tigers

Detroit defeated Boston, 4–2, in the opener of a three-game series, extending the Red Sox' losing streak to five games. Starter Garrett Richards allowed three runs on five hits in four innings and took the loss. Hunter Renfroe homered. Boston won the middle game of the series, 4–1, as Eduardo Rodríguez improved to 8–6 on the season, allowing no runs on two hits in five innings. J. D. Martinez, Kiké Hernández, and Jarren Duran each homered, while Matt Barnes notched his 24th save of the season. The Tigers won the final game, 8–1. Red Sox starter Martín Pérez left after 1+1⁄3 innings, having allowed three runs on five hits, and took the loss. Alex Verdugo drove in Boston's only run.

Red Sox lost the series 1–2 (7–13 runs)

August 6–August 8, at Toronto Blue Jays

Toronto won the first game of a four-game series, 12–4, powered by a nine-run fifth inning. Starter Nathan Eovaldi allowed seven of those runs, and took the loss. Infielder Jonathan Araúz pitched the bottom of the eighth inning for Boston. Hunter Renfroe homered. Toronto won the second game of the series (also the first game of a doubleheader), 1–0. Each team only had two hits. The game's only score was a walk-off home run hit by Marcus Semien off of Matt Barnes to start the bottom of the seventh inning. The Red Sox won the second game of the doubleheader, scheduled for seven innings, 2–1 in eight innings. With Toronto holding a 1–0 lead entering the sixth, Alex Verdugo homered to tie the contest. With no further scoring through the seventh, Boston scored one run in the eighth, driven in by Araúz. Adam Ottavino then held the Blue Jays scoreless to earn his eighth save of the season. The win went to Barnes, who had pitched the seventh inning; starter Tanner Houck went 3+2⁄3 innings and had a no decision. Toronto won the final game of the series, 9–8, overcoming a 7–2 Boston lead after four innings. Red Sox starter Garrett Richards allowed four runs (three earned) on six hits in five innings, while Barnes took the loss after allowing a three-run homer to George Springer in the eighth inning. J. D. Martinez was 4-for-5 with three RBIs and Kevin Plawecki was 3-for-4 also with three RBIs.

Red Sox lost the series 1–3 (14–23 runs)

August 10–August 12, vs. Tampa Bay Rays

Boston had a 4–1 lead in the first game of a three-game home series, but Tampa Bay rallied for an 8–4 win. It was the 10th Red Sox loss in 12 games. Starter Eduardo Rodríguez went 5+1⁄3 innings while allowing two runs on four hits; Matt Barnes took the loss in relief after allowing four runs on two hits in 2⁄3 of an inning. Rafael Devers and Hunter Renfroe homered. Boston recovered in the second game of the series with a 20–8 win, the most Red Sox runs scored in a single game since the 2015 season.^[94] Bobby Dalbec had 5 RBIs on the night, and Renfroe and Xander Bogaerts each added 4 RBIs of their own. Boston's 19 hits included only one home run, by Bogaerts. Starter Nathan Eovaldi tossed seven innings of three-hit ball, surrendering one run, and earned his 10th win of the season. The Rays’ Josh Fleming was charged with 10 earned runs in 3+1⁄3 innings pitched. Tampa Bay won the final game of the series, 8–1. Red Sox starter Tanner Houck allowed four runs (three earned) on six hits in five innings, and took the loss. Devers drove in Boston's only run.

Red Sox lost the series 1–2 (25–24 runs)

August 13–August 15, vs. Baltimore Orioles

Boston won the opener of a three-game home series against the Orioles, 8–1. Starter Nick Pivetta went six innings and got the win, improving to 9–5 on the season, while Garrett Richards pitched the final three innings to earn a save. Bobby Dalbec was 3-for-4 with a home run and three RBIs. Xander Bogaerts and Hunter Renfroe also homered. Kyle Schwarber made his Red Sox debut, going 0-for-2 with two walks and two runs scored as the DH. The second game of the series marked the return of Chris Sale to the Red Sox, following his Tommy John surgery and subsequent rehabilitation. Sale went five innings while allowing two runs on six hits and earned the win as Boston defeated Baltimore, 16–2. Alex Verdugo went 4-for-5 with an RBI and three runs scored. The Red Sox had two home runs from Dalbec, and one each from Renfroe, Rafael Devers, and J. D. Martinez. Boston completed the sweep with a 6–2 win in the third game of the series. Starter Eduardo Rodríguez earned his ninth win of the season, holding the Orioles to one unearned run on three hits in six innings. Martinez again homered, and had three RBIs.

Red Sox won the series 3–0 (30–5 runs)

August 17–August 18, at New York Yankees

Boston opened a three-game road series in New York with a loss in the first game of a doubleheader, 5–3. Starter Tanner Houck had a no decision after holding the Yankees to two runs on five hits in four innings. Reliever Garrett Whitlock allowed two runs in 1⁄3 of an inning and took the loss. Christian Vázquez had a solo home run, while Xander Bogaerts had the other two RBIs for Boston. The second game of the doubleheader was also won by the Yankees, 2–0. Both runs were scored off of Red Sox starter Nathan Eovaldi in his five innings of work, dropping him to 10–8 on the season. Boston was limited to five hits, all singles, and four walks. The loss left Boston (69–53) in third place in the AL East standings, a percentage point behind the Yankees (68–52).^[95] The Yankees completed their sweep with a 5–2 win in the third game of the series. Boston's runs came on solo homers by Bogaerts (first inning) and Hunter Renfroe (ninth inning). Starter Nick Pivetta took the loss after allowing four runs on four hits in 1+2⁄3 innings.

Red Sox lost the series 0–3 (5–12 runs)

August 20–August 23, vs. Texas Rangers

The Red Sox opened a three-game home series with a 6–0 win over the Rangers. Starter Chris Sale went five innings, allowing five hits, and got the win. Xander Bogaerts hit his 20th home run of the season. Texas won the second game of the series, 10–1, with Kiké Hernández driving in Boston's only run. Starter Eduardo Rodríguez took the loss after allowing five runs on eight hits in 3+2⁄3 innings. The Red Sox were limited to five hits, while also committing five errors. The final game of the series was postponed a day, due to the effects of Hurricane Henri.^[96] The Red Sox won that game, 8–4 in 11 innings. Starter Nathan Eovaldi held Texas to one run on four hits in seven innings and left with a 3–1 lead, but ultimately received a no decision. With Boston still holding a 3–1 lead entering the top of the ninth, the Rangers scored twice off of closer Matt Barnes to tie the game. The game went to extra innings, and both teams scored a single run in the 10th inning. In the 11th inning, the Rangers did not score, and the Red Sox won the game on a walk-off grand slam by Travis Shaw. Reliever Garrett Whitlock got the win after pitching the final 2+2⁄3 innings for Boston. In addition to Shaw, Alex Verdugo and Hunter Renfroe also homered.

Red Sox won the series 2–1 (15–14 runs)

August 24–August 26, vs. Minnesota Twins

The opener of a three-game home series against Minnesota was an 11–9 Boston win. Starter Tanner Houck had a no decision after allowing three runs on eight hits in 4+2⁄3 innings. Reliever Josh Taylor, who recorded one out on one pitch to close out the fifth inning, got the win. Closer Matt Barnes allowed a home run and two walks while recording no outs in the ninth inning. He was relieved by Hansel Robles, who earned the save, his 11th of the season and first with the Red Sox. Boston hitters had four home runs: two by Hunter Renfroe and one each by Travis Shaw and Kiké Hernández. The Twins won the second game of the series, 9–6 in 10 innings. Red Sox starter Nick Pivetta allowed four runs on six hits in four innings. Boston did not score until the seventh inning, and entered the bottom of the ninth trailing, 4–2. A two-run home run by Kyle Schwarber tied the game, which then went to extra innings. Robles came in to pitch the 10th for Boston, and allowed five runs via two homers. Robles took the loss after the Red Sox only scored twice in their half of the inning, one run coming on a Hernández homer. The final game of the series was a 12–2 victory by the Red Sox, with Chris Sale getting the win after holding the Twins to two runs on two hits in 5+1⁄3 innings. Rafael Devers hit his 30th home run of the season, while Bobby Dalbec homered twice and drove in seven runs.

Red Sox won the series 2–1 (29–20 runs)

August 27–August 29, at Cleveland Indians

The Red Sox defeated the Indians, 4–3, in the first game of a three-game series. Prior to the game, Kiké Hernández and Christian Arroyo were placed on the COVID-related injured list.^[97] Starter Eduardo Rodríguez notched his 10th win of the season after holding Cleveland to three runs on eight hits in seven innings. Adam Ottavino got the save. Jonathan Araúz, just called up from Triple-A, had a three-run homer, one of only three Boston hits. Boston also won the second game of the series, 5–3 in 10 innings. Starter Nathan Eovaldi went 5+1⁄3 innings while allowing two runs on six hits. Kyle Schwarber had a first-inning home run, helping to stake the Red Sox to an early 2–0 lead. After Cleveland tied the game, 2–2, in the second inning, there was no more scoring until extra innings. J. D. Martinez put the Red Sox ahead on a three-run homer. The Indians got one run back off of Martín Pérez, who was relieved by Ottavino who earned his 10th save of the season. The win went to Garrett Whitlock, who pitched a scoreless inning as the sixth of eight total Boston pitchers. The Twins won the final game of the series, 7–5, despite Boston building a 4–0 lead after five innings. Starter Tanner Houck went 5+1⁄3 innings and allowed three runs on one hit and four walks. Austin Davis, the fourth of five Boston pitchers, allowed three runs on three hits and took the loss. Rafael Devers had two home runs and Bobby Dalbec had one.

Red Sox won the series 2–1 (14–13 runs)

August 30–August 31, at Tampa Bay Rays

The Red Sox lost the opener of a four-game series in Tampa Bay, 6–1. Relievers Martín Pérez and Matt Barnes were not available due to being placed on the COVID-related injured list.^[98] Starter Nick Pivetta allowed four runs on six hits in five innings and took the loss. A homer by Bobby Dalbec accounted for Boston's only run. Prior to the second game of the series, relievers Josh Taylor and Hirokazu Sawamura were also placed on the COVID-related list, and during the game, shortstop Xander Bogaerts was removed due to a positive test.^[99] Tampa Bay won the game, 8–5, with Boston starter Brad Peacock taking the loss in his Red Sox debut after allowing five runs on two hits in 2+1⁄3 innings. Kyle Schwarber homered. Boston ended the month in third place in the American League East, still in position for the postseason as a wild card, with a record of 75–59.

September

The Red Sox entered September with eight players unavailable due to positive COVID-19 testing or contact tracing: pitchers Matt Barnes, Martín Pérez, Hirokazu Sawamura, and Josh Taylor; and position players Christian Arroyo, Xander Bogaerts, Kiké Hernández, and Yairo Muñoz.^[100][101] Three staff members were also unavailable due to testing or tracing: quality control coach Ramón Vázquez, first base coach Tom Goodwin, and conditioning coach Kiyoshi Momose.^[102] With a record of 75–59, and having just lost the first two games of a four-game series against Tampa Bay, the Red Sox were positioned as a wild card team, in third place in the AL East.

September 1–September 2, at Tampa Bay Rays (cont'd)

Boston won the third game of the series, 3–2. Starter Chris Sale went six innings, holding the Rays to two runs on six hits. Reliever Garrett Whitlock pitched two scoreless innings and got the win; Adam Ottavino earned the save, his 11th of the season. Christian Vázquez went 3-for-4 with a home run and two RBIs; Jarren Duran drove in Boston's other run, a go-ahead RBI in the ninth inning to break a 2–2 tie. The final game of the series was another Red Sox win, 4–0. Starter Eduardo Rodríguez went six innings and won his 11th game of the year. Garrett Richards pitched the final three innings, earning a save. Bobby Dalbec went 2-for-4 with two RBIs.

Red Sox split the series 2–2 (13–16 runs)

September 3–September 5, vs. Cleveland Indians

Prior to the first game against Cleveland, outfielder Jarren Duran became Boston's ninth player on the COVID-related list.^[103] The Red Sox opened the three-game series with an 8–5 win. Starter Nathan Eovaldi held Cleveland to three runs on six hits in 6+1⁄3 innings; he was relieved by Adam Ottavino, who was credited with the win; Garrett Whitlock earned a save. Kyle Schwarber had three RBIs, one coming on a leadoff home run in the first inning. Hunter Renfroe also drove in three runs, via a seventh-inning home run with two men on base. Kevin Plawecki and Jonathan Araúz each hit solo home runs. Boston also won the second game of the series, 4–3, the team's fourth consecutive win. Starter Tanner Houck kept the Indians scoreless through five innings, but ended up with a no decision. A three-run home run by Rafael Devers in the seventh inning gave the Red Sox a 3–0 lead; with his 33rd home run of the season, Devers reached 100 RBIs for the second time in his career.^[104] In the top of the ninth, Cleveland scored three runs off of Ottavino to tie the game. After Boston loaded the bases with two outs in the bottom of the ninth, Alex Verdugo singled to drive in the winning run. Prior to the final game of the series, pitcher Nick Pivetta and utility player Danny Santana were also added to the COVID-related list, bringing the Red Sox' total to 11 players.^[105] The final game was won by Cleveland, 11–5. After the Indians built a 6–0 lead after three innings, the Red Sox battled back within a run, 6–5, at the end of the sixth, only to have the Indians score five runs in the top of the ninth to put the game out of reach. Kutter Crawford, just called up from Triple-A and making his MLB debut, took the loss. J. D. Martinez went 3-for-5 with three RBIs and a home run.

Red Sox won the series 2–1 (17–19 runs)

September 6–September 8, vs. Tampa Bay Rays

Despite taking a 7–1 lead after the first two innings of the series' opening game, the Red Sox lost to the Rays, 11–10 in 10 innings. Boston committed four errors during the game, making six of Tampa Bay's runs unearned. Starter Chris Sale went 3+2⁄3 innings and allowed one earned run (five total runs) on 10 hits. Garrett Whitlock, the sixth of seven Red Sox pitchers, had a blown save and took the loss. Hunter Renfroe was 3-for-5 with two RBIs, and Jonathan Araúz homered. Home plate umpire Manny Gonzalez was struck by a foul tip in the first inning and had to leave the game.^[106] A rare instance of an intentional balk occurred in the bottom of the 10th inning, when the Rays, holding a two-run lead, had pitcher Collin McHugh intentionally commit a balk, thus advancing the Red Sox runner at second base to third base, in order to avoid the possibility of sign stealing.^[107] The game took four hours and 54 minutes to complete. The Rays also won the second game of the series, 12–7. Starter Eduardo Rodríguez look the loss after allowing six runs in 3+2⁄3 innings. Bobby Dalbec had two home runs and four RBIs. Danny Santana also homered. Boston won the final game of the series, 2–1. Scoreless through the first seven innings, the Rays scored once in the top of the eighth, and the Red Sox scored two runs in the bottom of the inning via a Renfroe home run with a runner on base. Renfroe also recorded an outfield assist on the final out of the game, as Tampa Bay's Joey Wendle attempted to stretch a double into a triple. Boston starter Nathan Eovaldi pitched seven scoreless innings but had a no decision, with the win going to Garrett Richards while Hansel Robles earned the save. The Red Sox' win put them back in second place of the AL East at 80–62 (.563), one-half game ahead of the New York Yankees at 78–61 (.561), with both teams in position as postseason wild cards.^[108]

Red Sox lost the series 1–2 (19–24 runs)

September 10–September 12, at Chicago White Sox

Prior to the opener of a three-game series in Chicago, Xander Bogaerts was activated from the COVID-related list,^[109] while Chris Sale and Jonathan Araúz were added to that list.^[110][111] In the opener, Chicago took a 4–0 lead through four innings, and while the Red Sox then scored three unanswered runs, the game ended 4–3 in the White Sox' favor. Starter Tanner Houck allowed all of Chicago's runs and left after 3+2⁄3 innings, his record falling to 0–4. Bobby Dalbec hit his 21st home run of the season. Boston won the second game of the series, 9–8 in 10 innings. Prior to the game, utility player Danny Santana was again added to the COVID-related list.^[112] Boston starter Connor Seabold, making his MLB debut, allowed two runs on three hits in three innings. Garrett Whitlock, the sixth of seven Boston pitchers, earned the win, with Josh Taylor notching his first major-league save. Travis Shaw was 2-for-5 with a home run and four RBIs. On the day of the final game of the series, reliever Phillips Valdéz became the latest Boston player added to the COVID-related list.^[113] Chicago won the game, 2–1. After the White Sox took a 1–0 lead in the bottom of the sixth, the Red Sox tied the game via an Alex Verdugo sacrifice fly in the top of the ninth. Leury García then hit a walk-off home run off of Whitlock with two outs in the bottom of the ninth. Boston starter Nick Pivetta held Chicago to one run on three hits in 5+1⁄3 innings. The loss dropped the Red Sox (81–64; 0.5586) back to third place in the AL East, with Toronto (80–63; 0.5594) moving into second place.

Red Sox lost the series 1–2 (13–14 runs)

September 13–September 15, at Seattle Mariners

Boston lost the opener of a three-game series in Seattle, 5–4. Starter Eduardo Rodríguez went six innings, allowing one run on six hits. A three-run homer by Seattle's Mitch Haniger off of Red Sox reliever Ryan Brasier put the Mariners ahead, 5–2, in the seventh inning. The runs were unearned, due to a two-out error by first baseman Kyle Schwarber. Back-to-back solo homers by Xander Bogaerts and Rafael Devers in the eighth inning left the Red Sox a run short. José Iglesias also homered. The loss dropped the Red Sox (81–65; 0.555) to fourth place in the AL East, percentage points behind the Yankees (80–64; 0.556). The Red Sox won the second game of the series, 8–4. Starter Nathan Eovaldi allowed two runs on five hits in five innings. Entering the eighth inning with the score tied, 2–2, Boston scored five runs, which proved to be enough to win. Schwarber had a three-RBI pinch hit double as part of the eighth inning rally. Adam Ottavino, the third of six Red Sox pitchers, threw only two pitches and recorded a single out, but got the win. J. D. Martinez, Bobby Dalbec, and Alex Verdugo each homered. Game 3 of the series, an afternoon getaway game, was tied 3–3 after nine innings. All of Seattle’s three runs had been allowed by Sox starter Tanner Houck, who pitched 4+1⁄3 innings. Boston’s three runs were made up of a Hunter Renfroe solo homer, a Kevin Plawecki RBI ground out, and a José Iglesias RBI double. Entering the top of the 10th, the Boston offense immediately went to work, as Jack López advanced to third base and then scored on a passed ball to give the Red Sox the lead. J. D. Martinez made it 5–3 on an RBI single before Kyle Schwarber came through in the clutch for the second straight game, delivering a two-run hit to shallow right field. Martinez and Schwarber were then driven in by Christian Vázquez, giving the Red Sox a 9–3 lead. Martín Pérez pitched the bottom of the tenth. Seattle scored one run but was otherwise effectively shut down, and the Red Sox won, 9–4, to win the series against the Mariners.

Red Sox won the series 2–1 (21–13 runs)

September 17–September 19, vs. Baltimore Orioles

The Red Sox began their final home stand of the season with a 7–1 win over the Orioles; it was Baltimore's 100th loss. Boston starter Chris Sale, just activated from the COVID-related list, got the win after holding the Orioles to one run on two hits in five innings. Hunter Renfroe had three RBIs, Alex Verdugo had three hits, and Bobby Dalbec homered. The win moved Boston back to second place in the AL East, slightly ahead of the Yankees and Blue Jays, with the three teams contesting for two wild card spots in the postseason. Boston won the second game of the series, 9–3, with reliever Tanner Houck earning the win. Starter Nick Pivetta went 3+2⁄3 innings and left with the game tied, 3–3. Xander Bogaerts went 3-for-5 with four RBIs and hit his 22nd home run of the season; Rafael Devers also went 3-for-5. Boston won the final game of the series, 8–6, to complete the sweep. Starter Nathan Eovaldi allowed three runs on seven hits in five innings, and had a no decision. Reliever Hirokazu Sawamura got the win and Garrett Richards earned a save. J. D. Martinez homered.

Red Sox won the series 3–0 (24–10 runs)

September 21–September 22, vs. New York Mets

The Red Sox opened a two-game series against the Mets with a 6–3 win. Starter Eduardo Rodríguez had a no decision after allowing two runs on five hits in 4+1⁄3 innings. Reliever Ryan Brasier got the win. Kiké Hernández and Xander Bogaerts homered. Boston won the second game of the series, 12–5. Starter Chris Sale earned the win to reach 5–0 on the season. Kyle Schwarber had two home runs to reach 31 on the season (including ones he hit before joining the Red Sox). The two wins over the Mets extended the Red Sox' winning streak to seven games, five of which came with the team wearing their yellow "City Connect" alternate uniforms.^[114]

Red Sox won the series 2–0 (18–8 runs)

September 24–September 26, vs. New York Yankees

The Red Sox opened their final home series of the season with an 8–3 loss to the Yankees. The loss reduced the Red Sox' lead in the AL wild card race to a single game over the Yankees, the teams holding records of 88–66 (.571) and 87–67 (.565), respectively. Starter Nathan Eovaldi took the loss after allowing seven runs on seven hits in 2+2⁄3 innings. Rafael Devers hit his 35th home run of the season. The Yankees won the second game of the series, 5–3. Boston starter Nick Pivetta held New York to one run on three hits in 5+1⁄3 innings. With the Red Sox holding a 3–1 lead entering the eighth inning, Yankees designated hitter Giancarlo Stanton hit a grand slam off of Red Sox reliever Darwinzon Hernández; two of the runs were charged to prior reliever Tanner Houck, who took the loss. Bobby Dalbec and Kevin Plawecki homered for Boston. Both teams ended the day with records of 88–67 (.568), tied in the AL wild card race. The Yankees completed the sweep with a 6–3 win on Sunday Night Baseball, powered by a four-run eighth inning. Boston starter Eduardo Rodríguez went five innings, holding the Yankees to two runs on six hits. Reliever Garrett Richards allowed two of the eighth-inning runs and took the loss. The loss put the Yankees atop the AL wild card race at 89–67 (.571) with the Red Sox one game back at 88–68 (.564) and the Blue Jays one more game back at 87–69 (.558). The top two wild card teams qualify for a single-game playoff, hosted by the top wild card team, with the winner advancing to the American League Division Series.

Red Sox lost the series 0–3 (9–19 runs)

September 28–September 30, at Baltimore Orioles

The Red Sox lost the opener of a three-game series in Baltimore, 4–2. Starter Chris Sale allowed three runs on four hits in 5+1⁄3 innings and took the loss. Boston was limited to three hits, one a Kyle Schwarber home run. The day ended with Boston (88–69) still holding the second AL wild card spot, two games behind the Yankees (90–67), a half-game game ahead of Seattle (88–70) and a full game ahead of Toronto (87–70). Boston won the second game of the series, 6–0, to snap a four-game losing streak. Starter Nathan Eovaldi got the win after holding the Orioles to four hits in six innings. J. D. Martinez went 3-for-4 with a home run and three RBIs; Hunter Renfroe also homered. As the Yankees lost to the Blue Jays, Boston (89–69) ended the day one game behind the Yankees (90–68) in the wild card race, with Seattle (89–70) and Toronto (88–70) still in contention. The Orioles won the final game of the series, 6–2. Starter Nick Pivetta took the loss after allowing three runs on four hits in 4+2⁄3 innings. Kiké Hernández homered for the Red Sox. The loss dropped the Red Sox into a tie with the Mariners for the second AL wild card spot, both teams with 89–70 records.

Red Sox lost the series 1–2 (10–10 runs)

October

Boston entered October having lost five of their last six games, with three games left to play in the regular season. With the Yankees (91–68) holding the top wild card spot in the American League, the Red Sox (89–70) and Mariners (89–70) were tied for the second wild card spot, followed by the Blue Jays (88–71).

October 1–October 3, at Washington Nationals

To open the final series of the regular season, the Red Sox defeated the Nationals, 4–2. Starter Eduardo Rodríguez got the win after holding Washington scoreless through five innings, and Hansel Robles earned a save. Hunter Renfroe and Bobby Dalbec homered. The Red Sox pulled within a game of the Yankees, who lost to the Rays, for the top wild card spot. The Mariners lost to the Angels, while the Blue Jays stayed in contention by beating the Orioles. Records at the end of October 1: Yankees (91–69), Red Sox (90–70), Mariners (89–71), Blue Jays (89–71)

Boston won the second game against Washington, 5–3. Starter Tanner Houck did not allow a baserunner in five innings of work, striking out eight of the 15 batters he faced, but received a no decision.^[115] Austin Davis, the fifth of six Red Sox pitchers, got the win, with Robles again earning a save. Rafael Devers and Kike Hernández both homered. With the Yankees losing to the Rays, the Red Sox moved into a tie for the top AL wild card spot. The Blue Jays stayed in contention with a win over the Orioles, as did the Mariners via a late rally to defeat the Angels. Records at the end of October 2: Red Sox (91–70), Yankees (91–70), Mariners (90–71), Blue Jays (90–71)

Boston completed a sweep of the Nationals with a 7–5 come-from-behind win. Starter Chris Sale was lifted after 2+1⁄3 innings, having allowed two runs on four hits and three walks. Trailing 5–1 after five innings, the Red Sox scored once in the sixth and three times in the seventh to tie the game. A two-run home run by Devers in the ninth inning, his second homer of the game, provided the winning margin.^[116] The win went to Eduardo Rodríguez, who pitched an inning in relief, with the save going to Nick Pivetta, who also pitched out of the bullpen as Boston used a total of seven pitchers.^[117] With the Yankees beating the Rays, Boston and New York ended in a tie atop the AL wild card standings, with Boston earning home field advantage via their 10–9 regular-season head-to-head record against New York.^[118] Records at the end of October 3: Red Sox (92–70), Yankees (92–70), Blue Jays (91–71), Mariners (90–72).

Red Sox won the series 3–0 (16–10 runs)