The 2021–22 Belgian Cup, called the Croky Cup for sponsorship reasons, was the 67th season of Belgium's annual football cup competition. The competition began on 25 July 2021 and ended with the final on 18 April 2022. The winners of the competition qualified for the 2022–23 UEFA Europa League play-off round.

The competition consists of one preliminary round, followed by ten proper rounds. All rounds were single-match elimination rounds, with the exception of the semi-finals which are again held over two legs. When tied after 90 minutes in the first three rounds, penalties were taken immediately. From round four, when tied after 90 minutes first an extra time period of 30 minutes was played, then penalties were taken if still necessary.

Teams entered the competition in different rounds, based upon their 2021–22 league affiliation. Teams from the fifth-level Belgian Division 3 or lower began in round 1, with the exception of six teams from the Belgian Provincial Leagues which were randomly drawn to start in the preliminary round. Belgian Division 2 teams entered in round 2, Belgian National Division 1 teams entered in round 3, Belgian First Division B teams in round 5 (except two already in round 3) and finally the Belgian First Division A teams entered in round 6 (except two already in round 5).

This round of matches were played on 25 July 2021^[1] and included six teams playing in the Belgian Provincial Leagues.

This round of matches were played on 31 July and 1 August 2021.^[1]

This round of matches was played on 7 and 8 August 2021^[1] and included the 110 winners from the First Round together with 48 teams playing in the Belgian Division 2.

This round of matches were played from 14 till 18 August 2021^[1] and includes the 79 winners from the Second Round together with 15 teams playing in the Belgian National Division 1 and 2 teams from the Belgian First Division B.

This round of matches were played from 21 till 25 of August 2021^[1] and includes the 48 winners from the Third Round.

This round of matches was scheduled to be played on 29 August 2021^[1] and included the 24 winners from the Fourth Round together with 6 teams from the Belgian First Division B and 2 teams from the Belgian First Division A. In the end, the matches were spread over multiple weeks, with the final fixture almost a month later on 21 September, mainly to accommodate the teams from the professional leagues which had already started their season.

RFC Liège (3) v Westerlo (2)

5 September 2021 Match 265	RFC Liège (3)	1–3	Westerlo (2)	Liège
16:00 CEST	Mouchamps 24'		Vaesen 37' Dierckx 42' (pen.), 90'	Stadium: Stade de Rocourt

Excel Mouscron (2) v Wellen (5)

14 September 2021 Match 266	Excel Mouscron (2)	3–1[D]	Wellen (5)
20:00 CEST	Ribeiro Costa 19' Chevalier 23' (pen.) Gueye 49'		Versteeven 62' (pen.)

Lyra-Lierse Berlaar (4) v Deinze (2)

14 September 2021 Match 267	Lyra-Lierse Berlaar (4)	0–5	Deinze (2)
19:30 CEST			De Belder 17', 26' Vets 43' (o.g.) Prychynenko 63' Mertens 80'

Onhaye (5) v Aalst (4)

29 August 2021 Match 268	Onhaye (5)	1–0 (a.e.t.)	Aalst (4)
16:00 CEST	Lorenzon 96'

Francs Borains (3) v Hoogstraten (4)

29 August 2021 Match 269	Francs Borains (3)	3–1	Hoogstraten (4)
16:00 CEST	Caufriez 39' (pen.), 42' Habbas 59'		Kuijlaars 79'

Dender EH (3) v Waasland-Beveren (2)

4 September 2021 Match 270	Dender EH (3)	1–0	Waasland-Beveren (2)
18:00 CEST	Hens 81'

Lierse Kempenzonen (2) v Rupel Boom (3)

4 September 2021 Match 271	Lierse Kempenzonen (2)	2–0	Rupel Boom (3)
20:00 CEST	Van Acker 52' Limbombe 57'

RAAL La Louvière (4) v Dikkelvenne (4)

29 August 2021 Match 272	RAAL La Louvière (4)	4–2	Dikkelvenne (4)
16:00 CEST	Soumaré 12' Romeyns 14' Djoum 39' Azevedo-Janelas 68'		Verheuge 51' Van Peteghem 71'

Visé (3) v RWDM (2)

4 September 2021 Match 273	Visé (3)	0–1	RWDM (2)
19:30 CEST			Libert 81'

Knokke (3) v RC Gent (4)

29 August 2021 Match 274	Knokke (3)	3–2 (a.e.t.)	RC Gent (4)
16:00 CEST	Vandewalle 7' Savaete 37' Koçur 120' (pen.)		Vankerkhoven 5' Volckaert 90'

Belisia (4) v Zwarte Leeuw (5)

29 August 2021 Match 275	Belisia (4)	1–0	Zwarte Leeuw (5)
16:00 CEST	Emens 76'

Union SG (1) v Lebbeke (5)

21 September 2021 Match 276	Union SG (1)	7–0	Lebbeke (5)	Forest, Brussels
20:30 CEST	Mitoma 16' Burgess 53' Avenatti 57' Aeyels 60' (o.g.) Undav 82' Lazare 84' Teuma 90' (pen.)			Stadium: Stade Joseph Marien

Tienen (3) v Jodoigne (5)

29 August 2021 Match 277	Tienen (3)	1–0	Jodoigne (5)
16:00 CEST	Mputu 50'

Diegem (4) v Lommel (2)

15 September 2021 Match 278	Diegem (4)	2–4	Lommel (2)
20:00 CEST	Egerickx 6' Deflem 60'		Roque 11' Kis 36' Vandersmissen 70' Saito 78'

Lokeren-Temse (4) v Seraing (1)

15 September 2021 Match 280	Lokeren-Temse (4)	0–3	Seraing (1)
20:00 CEST			Mikautadze 7', 55', 88'

The draw for the sixth round was made on 24 September 2021, a few days after the conclusion of the last match of the previous round. Newly entering at this round were the teams from the Belgian First Division A, with the exception of Union SG and Seraing which had entered in the prior round. The 16 teams entering at this stage were seeded and could not meet each other. The lowest team still in the competition was Onhaye, from the Belgian Division 3 (tier 5).

KV Oostende (1) v Onhaye (5)

26 October 2021	KV Oostende (1)	8–1	Onhaye (5)	Oostende
20:00 CEST	Kvasina 5', 26', 41' Fortès 37' Atanga 50', 60' Ambrose 75' (pen.) Ndicka 80'		Delplank 3'	Stadium: Diaz Arena

RWDM (2) v Zulte Waregem (1)

26 October 2021	RWDM (2)	1–2	Zulte Waregem (1)	Molenbeek-Saint-Jean
20:30 CET	Nangis 40'		Kutesa 1' Vossen 90+2' (pen.)	Stadium: Edmond Machtens Stadium

KV Mechelen (1) v Union SG (1)

26 October 2021	KV Mechelen (1)	2–1	Union SG (1)	Mechelen
20:30 CEST	Shved 16' Hairemans 65'		Vanzeir 82'	Stadium: AFAS-stadion Achter de Kazerne Referee: Arthur Denil

Excel Mouscron (2) v Standard Liège (1)

26 October 2021	Excel Mouscron (2)	0–1	Standard Liège (1)	Mouscron
20:45 CEST			Klauss 7' (pen.)	Stadium: Stade Le Canonnier Attendance: 4,000 Referee: Alexandre Boucaut

Dender EH (3) v K.A.S.Eupen (1)

27 October 2021	Dender EH (3)	0–1	K.A.S.Eupen (1)
20:00 CET			Gnaka 7'

Sint-Eloois-Winkel (3) v K.R.C. Genk (1)

27 October 2021	Sint-Eloois-Winkel (3)	0–6	K.R.C. Genk (1)	Sportpark Terschueren, Sint-Eloois-Winkel
20:00 CEST			Ugbo 34' (pen.), 80' Arteaga 36', 38' Paintsil 44' Toma 87'

K.A.A. Gent (1) v Belisia (4)

27 October 2021	K.A.A. Gent (1)	4–0	Belisia (4)	Ghelamco Arena, Gent
20:00 CEST	Odjidja-Ofoe 6' Okumu 25' Mboyo 43' Chakvetadze 64' (pen.)

Knokke (3) v Kortrijk (1)

27 October 2021	Knokke (3)	1–1 (a.e.t.) (1–2 p)	Kortrijk (1)
20:00 CET	Lambo 79'		Kadri 51'
	Penalties
	Mariën Binst Van den Bossche Vanraefelghem Bailly		D'haene Rougeaux Palaversa Sainsbury

R.F.C. Seraing (1) v Sint-Truidense V.V. (1)

27 October 2021	R.F.C. Seraing (1)	3–2 (a.e.t.)	Sint-Truidense V.V. (1)
20:00 CET	Mouandilmadji 35' Maziz 80', 104'		Matsubara 53' Koita 57'

Francs Borains (3) v K Beerschot VA (1)

27 October 2021	Francs Borains (3)	0–4	K Beerschot VA (1)
20:30 CET			Noubissi 2' Caicedo 58' Holzhauser 80' Vaca 90'

Club Brugge (1) v Deinze (2)

27 October 2021	Club Brugge (1)	3–0	Deinze (2)	Jan Breydelstadion, Brugge
20:45 CEST	Izquierdo 48' Dost 74', 77'

Lierse Kempenzonen (2) v OH Leuven (1)

27 October 2021	Lierse Kempenzonen (2)	1–2	OH Leuven (1)
20:45 CET	Liongola 80'		Kaba 62' (pen.), 86'

RAAL La Louvière (4) v R.S.C. Anderlecht (1)

27 October 2021	RAAL La Louvière (4)	1–7	R.S.C. Anderlecht (1)	Stade Communal du Tivoli, La Louvière
20:45 CEST	Franco 35' (pen.)		Zirkzee 20', 45' Hoedt 32', 90' Refaelov 39', 79' Raman 75'

Cercle Brugge (1) v K.V.K. Tienen (3)

28 October 2021	Cercle Brugge (1)	3–0	K.V.K. Tienen (3)	Jan Breydelstadion, Brugge
20:00 CEST	Denkey 33' Matondo 42' Cassaert 63'

K.V.C. Westerlo (2) v R.Antwerp F.C. (1)

28 October 2021	K.V.C. Westerlo (2)	2–1	R.Antwerp F.C. (1)
20:00 CET	Van den Keybus 32' Foster 44'		Samatta 75'

The draw for the seventh round was made on 28 October 2021, immediately after completion of the last match of round six between Westerlo and Antwerp. Lommel and Westerlo, both playing in the Belgian First Division B (tier 2) are the only teams left not playing at the highest level. Matches will be played mid-week from 30 November 2021 to 2 December 2021.

R.F.C. Seraing (1) v R.S.C. Anderlecht (1)

30 November 2021	R.F.C. Seraing (1)	3–3 (a.e.t.) (3–4 p)	R.S.C. Anderlecht (1)	Seraing
20:45 CET	Maziz 10' (pen.), 60' Mikautadze 17' (pen.)	Report	Kouamé 39', 41' Refaelov 50' (pen.)	Stadium: Stade du Pairay Referee: Bert Put
	Penalties
	Del Fabro Nadrani Sanogo Mikautadze Maziz		Gómez Amuzu Cullen Verschaeren Murillo

K.R.C. Genk (1) v Club Brugge (1)

1 December 2021	K.R.C. Genk (1)	3–3 (a.e.t.) (3–5 p)	Club Brugge (1)	Genk
20:45 CET	Thorstvedt 29' Paintsil 45+2', 71'		Balanta 7' De Ketelaere 69', 90'	Stadium: Cegeka Arena
	Penalties
	Hrošovský Lucumí Bongonda Thorstvedt		Dost De Ketelaere Rits Ricca Lang

The draw for the quarter-finals was made right after the conclusion of the last match of the previous round.

The draw for the semi-finals was made right after the conclusion of the last match of the previous round.

First legs

K.A.A. Gent (1) v Club Brugge (1)

2 February 2022	K.A.A. Gent (1)	0–1	Club Brugge (1)	Ghent
20:45 CET		Report	De Ketelaere 56'	Stadium: Ghelamco Arena Referee: Nathan Verboomen

K.A.S. Eupen (1) v R.S.C. Anderlecht (1)

3 February 2022	K.A.S. Eupen (1)	2–2	R.S.C. Anderlecht (1)	Eupen
20:45 CET	Prevljak 16' (pen.) Peeters 78'		Refaelov 6' (pen.), 90+6' (pen.)	Stadium: Kehrwegstadion Referee: Jonathan Lardot